Porphyromonas gingivalis: an invasive and evasive opportunistic oral pathogen

N Bostanci, GN Belibasakis - FEMS microbiology letters, 2012 - academic.oup.com
Porphyromonas gingivalis is a Gram-negative oral anaerobe that is involved in the
pathogenesis of periodontitis, an inflammatory disease that destroys the tissues supporting …

TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk

J Brown, H Wang, GN Hajishengallis… - Journal of dental …, 2011 - journals.sagepub.com
Toll-like receptors play a critical role in innate immunity by detecting invading pathogens.
The ability of TLRs to engage different intracellular signaling molecules and cross-talk with …

Microbial manipulation of receptor crosstalk in innate immunity

G Hajishengallis, JD Lambris - Nature Reviews Immunology, 2011 - nature.com
In the arms race of host–microbe co-evolution, successful microbial pathogens have evolved
ingenious ways to evade host immune responses. In this Review, we focus on'crosstalk …

Molecular strategies underlying Porphyromonas gingivalis virulence

IL Silva, E Cascales - Journal of Molecular Biology, 2021 - Elsevier
The anaerobic Gram-negative bacterium Porphyromonas gingivalis is considered the
keystone of periodontitis diseases, a set of inflammatory conditions that affects the tissues …

Crosstalk pathways between Toll-like receptors and the complement system

G Hajishengallis, JD Lambris - Trends in immunology, 2010 - cell.com
The Toll-like receptors (TLRs) and complement are key innate defense systems that are
triggered rapidly upon infection. Although both systems have been investigated primarily as …

Immunological Pathways Triggered by Porphyromonas gingivalis and Fusobacterium nucleatum: Therapeutic Possibilities?

KQ De Andrade, CLC Almeida-da-Silva… - Mediators of …, 2019 - Wiley Online Library
Porphyromonas gingivalis (P. gingivalis) and Fusobacterium nucleatum (F. nucleatum) are
Gram‐negative anaerobic bacteria possessing several virulence factors that make them …

More than complementing Tolls: complement–Toll‐like receptor synergy and crosstalk in innate immunity and inflammation

G Hajishengallis, JD Lambris - Immunological reviews, 2016 - Wiley Online Library
Complement and Toll‐like receptors (TLR s) play key roles in the host immune response
and are swiftly activated by infection or other types of immunological stress. This review …

[HTML][HTML] Oral microbiota in the oral-genitourinary axis: identifying periodontitis as a potential risk of genitourinary cancers

S Yuan, C Fang, WD Leng, L Wu, BH Li… - Military Medical …, 2021 - Springer
Periodontitis has been proposed as a novel risk factor of genitourinary cancers: although
periodontitis and genitourinary cancers are two totally distinct types of disorders …

[HTML][HTML] Macrophages in periodontitis: A dynamic shift between tissue destruction and repair

L Yin, X Li, J Hou - Japanese Dental Science Review, 2022 - Elsevier
Periodontitis is a chronic inflammatory disease associated with a dysbiotic bacterial biofilm
in the subgingival environment that may disturb the balance between the oral microbiome …

[HTML][HTML] Macrophage-specific TLR2 signaling mediates pathogen-induced TNF-dependent inflammatory oral bone loss

G Papadopoulos, EO Weinberg, P Massari… - The Journal of …, 2013 - journals.aai.org
Porphyromonas gingivalis is a primary etiological agent of chronic periodontal disease, an
infection-driven chronic inflammatory disease that leads to the resorption of tooth-supporting …