Trypanosoma cruzi is the etiologic agent of Chagas disease, a neglected tropical disease
that affects millions of people mainly in Latin America. To establish a life-long infection, T …

Chagas disease, caused by the protozoan Trypanosoma cruzi, is a lifelong and debilitating
illness of major significance throughout Latin America and an emergent threat to global …

Although the genome of Trypanosoma cruzi, the causative agent of Chagas disease, was
first made available in 2005, with additional strains reported later, the intrinsic genome …

Background Visceral leishmaniasis (VL) is diagnosed by microscopic confirmation of the
parasite in bone marrow, spleen or lymph node aspirates. These procedures are unsuitable …

Global proteomic analyses of pathogens have thus far been limited to unicellular organisms
(eg, protozoa and bacteria). Proteomic analyses of most eukaryotic pathogens (eg …

The exovesicles (EVs) are involved in pathologic host-parasite immune associations and
have been recently used as biomarkers for diagnosis of infectious diseases. The release of …

The aim of this work was to determine the best strategy to display antigens (Ags) on
immunochemical devices to improve test selectivity and sensitivity. We comparatively …

Chagas Disease, caused by the protozoan Trypanosoma cruzi, is a major health and
economic problem in Latin America for which no vaccine or appropriate drugs for large …

Eukaryotic microorganisms have evolved ingenious mechanisms to generate variability at
their cell surface, permitting differential adherence, rapid adaptation to changing …

Malaria remains a significant global health burden. The development of an effective malaria
vaccine remains as a major challenge with the potential to significantly reduce morbidity and …