The dietary isoflavone daidzein mitigates oxidative stress, apoptosis, and inflammation in CDDP‐induced kidney injury in rats: Impact of the MAPK signaling pathway

A Tomar, S Kaushik, SI Khan, K Bisht… - … of Biochemical and …, 2020 - Wiley Online Library
Cisplatin‐induced nephrotoxicity persists as a clinical problem despite several supportive
measures to alleviate renal damage. Daidzein (DZ), a dietary isoflavone having antioxidant …

Effect of daidzein on cisplatin-induced hematotoxicity and hepatotoxicity in experimental rats

S Karale, JV Kamath - Indian journal of pharmacology, 2017 - journals.lww.com
Objective: The objective of the study was to investigate the effect of daidzein flavonoid on
cisplatin (CP)-induced hematotoxicity and hepatotoxicity in experimental rats. Materials and …

Treadmill exercise promotes neurogenesis in ischemic rat brains via caveolin-1/VEGF signaling pathways

Y Zhao, Q Pang, M Liu, J Pan, B Xiang, T Huang… - Neurochemical …, 2017 - Springer
Using a model of middle cerebral artery occlusion (MCAO), we have previously
demonstrated that treadmill exercise promotes angiogenesis in the ischemic penumbra …

Daidzein and its effects on brain

T Ahmed, S Javed, A Tariq, G Onofrio… - Current medicinal …, 2017 - ingentaconnect.com
Among naturally occurring isoflavones, soy isoflavones are an important class with various
biological activities. Due to their phytoestrogenic structure, their effects on the brain are …

Anti‐neuroinflammatory effect of daidzein in human hypothalamic GnRH neurons in an in vitro membrane‐based model

S Morelli, A Piscioneri, G Guarnieri, A Morelli… - …, 2021 - Wiley Online Library
Phytoestrogens can control high‐fat diet‐induced hypothalamic inflammation that is
associated with severe consequences, including obesity, type 2 diabetes, cardiovascular …

Chungkookjang, a soy food, fermented with Bacillus amyloliquefaciens protects gerbils against ishcmeic stroke injury, and post-stroke hyperglycemia

SY Jeong, T Zhang, X Wu, JY Qiu, S Park - Food research international, 2020 - Elsevier
Chungkookjang is a traditional Korean fermented soybean food with anti-diabetic and
thrombolytic activity. It may also have anti-stroke activity. We determined that chungkookjang …

[HTML][HTML] Bifidobacterium breve CCFM1025 Improves Sleep Quality via Regulating the Activity of the HPA Axis: A Randomized Clinical Trial

Y Lan, J Lu, G Qiao, X Mao, J Zhao, G Wang, P Tian… - Nutrients, 2023 - mdpi.com
Psychobiotics, a newly identified category of probiotics primarily targeting the gut–brain axis,
exhibit tremendous potential in improving sleep quality. In this study, the clinical trial was …

[HTML][HTML] Protective effect of daidzein against diethylnitrosamine/carbon tetrachloride-induced hepatocellular carcinoma in male rats

SAE Bashandy, H Ebaid, J Al-Tamimi, I Hassan… - Biology, 2023 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) claims the second-largest number of
casualties among all forms of cancer. Several chemotherapeutic agents are being used for …

[HTML][HTML] Phytoestrogen isoflavone intervention to engage the neuroprotective effect of glutamate oxaloacetate transaminase against stroke

S Khanna, R Stewart, S Gnyawali, H Harris… - The FASEB …, 2017 - ncbi.nlm.nih.gov
In the pathophysiologic setting of cerebral ischemia, excitotoxic levels of glutamate
contribute to neuronal cell death. Our previous work demonstrated the ability of glutamate …

Soy isoflavone daidzein protects Neuro2a cells from NO stress via activation of AMPK-PGC1α pathway followed by mitochondrial enhancement

S Ito, H Sasaki, T Gotow, I Suetake, K Nagai - PharmaNutrition, 2023 - Elsevier
Background Soy isoflavone daidzein protects cells from oxidative stress. Oxidative stress
causes several neurodegenerative diseases via damaging mitochondria and inducing cell …