Allergen immunotherapy is a form of therapeutic vaccination for established IgE-mediated
hypersensitivity to common allergen sources such as pollens, house dust mites and the …

During the last two decades, there has been broad interest in RNA-based technologies for
the development of prophylactic and therapeutic vaccines. Preclinical and clinical trials have …

Two decades ago successful transfection of antigen presenting cells (APC) in vivo was
demonstrated which resulted in the induction of primary adaptive immune responses. Due to …

mRNA therapy is a novel anticancer strategy based on in vitro transcription (IVT), which has
potential for the treatment of malignant tumors. The outbreak of the COVID-19 pandemic in …

In vitro-transcribed messenger RNA-based therapeutics represent a relatively novel and
highly efficient class of drugs. Several recently published studies emphasize the potential …

Increases in the world's population and population density promote the spread of emerging
pathogens. Vaccines are the most cost-effective means of preventing this spread. Traditional …

DNA vaccines have emerged as innovative approaches that have great potential to
overcome the limitations of current conventional vaccines. Plasmid DNA vaccines are often …

Synthetic mRNA has been considered as an emerging biotherapeutic agent for the past
decades. Recently, the SARS-CoV-2 pandemic has led to the first clinical use of synthetic …

Allergen‐specific immunotherapy (AIT) is an allergen‐specific form of treatment for patients
suffering from immunoglobulin E (IgE)‐associated allergy; the most common and important …

In recent years, vaccine development using ribonucleic acid (RNA) has become the most
promising and studied approach to produce safe and effective new vaccines, not only for …