Cardiovascular therapeutics: A new potential for anxiety treatment?

K Repova, S Aziriova, K Krajcirovicova… - Medicinal Research …, 2022 - Wiley Online Library
Besides the well‐recognized risk factors, novel conditions increasing cardiovascular
morbidity and mortality are emerging. Undesirable emotions and behavior such as anxiety …

Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal

PJ Harrison, EM Tunbridge, AC Dolphin… - The British Journal of …, 2020 - cambridge.org
We reappraise the psychiatric potential of calcium channel blockers (CCBs). First, voltage-
gated calcium channels are risk genes for several disorders. Second, use of CCBs is …

Drug repositioning for treatment-resistant depression: Hypotheses from a pharmacogenomic study

C Fabbri, S Kasper, J Zohar, D Souery… - Progress in Neuro …, 2021 - Elsevier
Abstract About 20–30% of patients with major depressive disorder (MDD) develop treatment-
resistant depression (TRD) and finding new effective treatments for TRD has been a …

Angiotensin receptor blockers are not just for hypertension anymore

JM Saavedra - Physiology, 2021 - journals.physiology.org
Beyond blood pressure control, angiotensin receptor blockers reduce common injury
mechanisms, decreasing excessive inflammation and protecting endothelial and …

Angiotensin-converting enzyme inhibitor rapidly ameliorates depressive-type behaviors via bradykinin-dependent activation of mammalian target of rapamycin …

H Luo, PF Wu, Y Cao, M Jin, TT Shen, J Wang… - Biological …, 2020 - Elsevier
Background Angiotensin-converting enzyme inhibitors (ACEIs) are widely prescribed
antihypertensive agents. Intriguingly, case reports and clinical trials have indicated that …

Impact of major depression on cardiovascular outcomes for individuals with hypertension: prospective survival analysis in UK Biobank

N Graham, J Ward, D Mackay, JP Pell, J Cavanagh… - BMJ open, 2019 - bmjopen.bmj.com
Objectives To assess whether a history of major depressive disorder (MDD) in middle-aged
individuals with hypertension influences first-onset cardiovascular disease outcomes …

Rates of delirium associated with calcium channel blockers compared to diuretics, renin-angiotensin system agents and beta-blockers: an electronic health records …

PJ Harrison, S Luciano… - Journal of …, 2020 - journals.sagepub.com
Background: Antihypertensive drugs, especially calcium channel blockers, have been
associated with differential rates of a number of neuropsychiatric outcomes. Delirium is …

The association of antihypertensive use and depressive symptoms in a large older population with hypertension living in Australia and the United States: a cross …

B Agustini, M Mohebbi, RL Woods, JJ McNeil… - Journal of human …, 2020 - nature.com
Cardiovascular drugs impact many pathways involved in depression pathophysiology and
treatment. However, their distinct impact on mood is underrecognized and the literature is …

Blockade of the angiotensin system improves mental health domain of quality of life: A meta-analysis of randomized clinical trials

DJ Brownstein, E Salagre, C Köhler… - Australian & New …, 2018 - journals.sagepub.com
Objective: It is unclear whether blockade of the angiotensin system has effects on mental
health. Our objective was to determine the impact of angiotensin converting enzyme …

Targeting the renin angiotensin system for the treatment of anxiety and depression

S Chrissobolis, AN Luu, RA Waldschmidt… - Pharmacology …, 2020 - Elsevier
Emotional disorders like anxiety and depression are responsible for considerable morbidity
and mortality all over the world. Several antidepressant and anxiolytic medications are …