Background: Although numerous cohort studies have reported an association between
antihypertensives use and depression, the exact effect of antihypertensives on depression …

Traumatic brain injury (TBI) results in complex pathological reactions, where the initial lesion
is followed by secondary inflammation and edema. Our laboratory and others have reported …

The major anti-hypertensive (AHT) drug classes have been associated with differential risks
of psychiatric disorders. However, existing data are limited largely to depression, and …

Cardio-vascular diseases (CVDs) and CVD-related disorders (including cerebrovascular
diseases; CBVDs) are a major public health concern as they represent the leading cause of …

Background Evidence is increasing that pathways of antihypertensives may have a role in
the pathogenesis of depression. However, how the class of antihypertensives affects …

Mood disorders include Major Depressive Disorder (MDD), Bipolar Disorder (BD) and
variations of both. Mood disorders has a public health significance with high comorbidity …

Background Arterial stiffness may contribute to late-life depression via cerebral
microvascular damage, but evidence is scarce. No longitudinal study has evaluated the …

Cerebral microvascular dysfunction may contribute to depression via disruption of brain
structures involved in mood regulation, but evidence is limited. The retina allows for …

BackgroundRecent work suggests that antihypertensive medications may be useful as
repurposed treatments for mood disorders. Using large-scale linked healthcare data we …

Background The discovery that voltage-gated calcium channel genes such as CACNA1C
are part of the aetiology of psychiatric disorders has rekindled interest in the therapeutic …