Degradation of the articular cartilage is at the centre of the pathogenesis of osteoarthritis
(OA), for which age is the major risk factor. Maintaining the chondrocytes in a healthy …

Senescence and autophagy play important roles in homeostasis. Cellular senescence and
autophagy commonly cause several degenerative processes, including oxidative stress …

The hallmark of OA is cartilage destruction, several factors such as catabolic enzymes and
chondrocyte death include apoptosis and/or autophagy are considered for the …

Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage
degradation and changes in the subchondral bone. Over the last two decades, there has …

Osteoarthritis (OA) is an age-related chronic progressive degenerative disease that induces
persistent pain and disabilities. The development of OA is a complex process, and the risk …

Osteoarthritis (OA) is one of the most common diseases leading to physical disability, with
age being the main risk factor, and degeneration of articular cartilage is the main focus for …

Objective miR-146a-5p was found to be significantly upregulated in cartilage tissue of
patients with osteoarthritis (OA). NUMB was shown to be involved in the autophagy …

Temporomandibular joint (TMJ), a site that is often impacted by osteoarthritis (OA), is
biomechanically linked with dental occlusion. Tissue responses in TMJ condyle to …

Objectives It has been suggested that the lysosomal recycling process called macro-
autophagy plays a role in osteoarthritis development. We thus decided to genetically ablate …

Osteoarthritis is a degenerative joint disease and a leading cause of adult disability. Our
previous study has reported that mesenchymal stem cell-derived exosomes (MSC-Exo) …