Tetrahedral framework nucleic acid inhibits chondrocyte apoptosis and oxidative stress through activation of autophagy

S Shi, T Tian, Y Li, D Xiao, T Zhang… - ACS Applied Materials …, 2020 - ACS Publications
Osteoarthritis (OA) is a degenerative articular cartilage pathogenic process that is
accompanied by excessive chondrocyte apoptosis. The occurrence of chondrocyte death …

[HTML][HTML] Correlation between gene expression and osteoarthritis progression in human

L Zhong, X Huang, M Karperien, JN Post - International journal of …, 2016 - mdpi.com
Osteoarthritis (OA) is a multifactorial disease characterized by gradual degradation of joint
cartilage. This study aimed to quantify major pathogenetic factors during OA progression in …

Too much death can kill you: inhibiting intrinsic apoptosis to treat disease

K Li, MF van Delft, G Dewson - The EMBO Journal, 2021 - embopress.org
Apoptotic cell death is implicated in both physiological and pathological processes. Since
many types of cancerous cells intrinsically evade apoptotic elimination, induction of …

[HTML][HTML] Knowledge mapping of autophagy in osteoarthritis from 2004 to 2022: a bibliometric analysis

J Liao, X Yu, J Chen, Z Wu, Q He, Y Zhang… - Frontiers in …, 2023 - frontiersin.org
Background Autophagy in osteoarthritis (OA) has become an active area of research with
substantial value and potential. Nevertheless, few bibliometric studies have systematically …

[HTML][HTML] Mechanism of HIFs in osteoarthritis

XA Zhang, H Kong - Frontiers in Immunology, 2023 - frontiersin.org
Osteoarthritis (OA) is a common disabling disease which has a high incidence rate in the
elderly. Studies have found that many factors are involved in the pathogenesis of OA …

Vertical inhibition of the PI3K/Akt/mTOR pathway for the treatment of osteoarthritis

J Chen, R Crawford, Y Xiao - Journal of cellular biochemistry, 2013 - Wiley Online Library
Osteoarthritis is characterized by degenerative alterations of articular cartilage including
both the degradation of extracellular matrix and the death of chondrocytes. The PI3K/Akt …

[HTML][HTML] Apoptosis in the extraosseous calcification process

F Boraldi, FD Lofaro, D Quaglino - Cells, 2021 - mdpi.com
Extraosseous calcification is a pathologic mineralization process occurring in soft connective
tissues (eg, skin, vessels, tendons, and cartilage). It can take place on a genetic basis or as …

Research progress on osteoarthritis treatment mechanisms

YT Gu, J Chen, ZL Meng, WY Ge, YY Bian… - Biomedicine & …, 2017 - Elsevier
Osteoarthritis is a common disease and is frequently encountered in the older population;
the incidence rises sharply with age. It is estimated that more than 360 million people suffer …

Inhibition of YAP with siRNA prevents cartilage degradation and ameliorates osteoarthritis development

Y Gong, SJ Li, R Liu, JF Zhan, C Tan, YF Fang… - Journal of Molecular …, 2019 - Springer
The Hippo/YAP signaling pathway is important for mediating organ size and tissue
homeostasis, but its role in osteoarthritis (OA) remains unclear. We aimed to investigate the …

Circular RNA expression profile of articular chondrocytes in an IL-1β-induced mouse model of osteoarthritis

Z Zhou, D Du, A Chen, L Zhu - Gene, 2018 - Elsevier
Osteoarthritis (OA) is a widely prevalent degenerative joint disease characterized by
articular cartilage degradation and joint inflammation. The pathogenesis of OA remains …