[HTML][HTML] Cytoprotective effects of delphinidin for human chondrocytes against oxidative stress through activation of autophagy
Antioxidant enzymes are decreased in osteoarthritis (OA) patients, implying the role of
oxidative stress in osteoarthritis pathogenesis. The aim of this study was to evaluate the …
oxidative stress in osteoarthritis pathogenesis. The aim of this study was to evaluate the …
[HTML][HTML] A new frontier in temporomandibular joint osteoarthritis treatment: Exosome-based therapeutic strategy
W Yuan, Y Wu, M Huang, X Zhou, J Liu, Y Yi… - … in Bioengineering and …, 2022 - frontiersin.org
Temporomandibular joint osteoarthritis (TMJOA) is a debilitating degenerative disease with
high incidence, deteriorating quality of patient life. Currently, due to ambiguous etiology, the …
high incidence, deteriorating quality of patient life. Currently, due to ambiguous etiology, the …
[HTML][HTML] The impact of forced joint exercise on lubricin biosynthesis from articular cartilage following ACL transection and intra-articular lubricin's effect in exercised …
OBJECTIVE: To evaluate the impact of forced joint exercise following acute knee injury on
lubricin metabolism and its relationship to cartilage degeneration and to assess …
lubricin metabolism and its relationship to cartilage degeneration and to assess …
[HTML][HTML] Leptin promotes apoptosis and inhibits autophagy of chondrocytes through upregulating lysyl oxidase-like 3 during osteoarthritis pathogenesis
ZM Huang, SH Du, LG Huang, JH Li, L Xiao… - Osteoarthritis and …, 2016 - Elsevier
Objective Leptin has been found highly expressed in human osteoarthritis. We aimed to
explore the possible effects and mechanisms of leptin on the apoptosis and autophagy of …
explore the possible effects and mechanisms of leptin on the apoptosis and autophagy of …
[HTML][HTML] mTOR: a potential therapeutic target in osteoarthritis?
B Pal, H Endisha, Y Zhang, M Kapoor - Drugs in R&D, 2015 - Springer
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by the progressive
loss of articular cartilage, remodeling of the subchondral bone, and synovial inflammation …
loss of articular cartilage, remodeling of the subchondral bone, and synovial inflammation …
Knockdown of hsa_circ_0134111 alleviates the symptom of osteoarthritis via sponging microRNA-224-5p
L Zhang, C Sui, Y Zhang, G Wang, Z Yin - Cell Cycle, 2021 - Taylor & Francis
The relevance of circular RNAs (circRNAs) has been indicated in the progression of various
diseases. Nevertheless, the precise function of circRNAs in osteoarthritis (OA) remains to be …
diseases. Nevertheless, the precise function of circRNAs in osteoarthritis (OA) remains to be …
[HTML][HTML] miR-4262 regulates chondrocyte viability, apoptosis, autophagy by targeting SIRT1 and activating PI3K/AKT/mTOR signaling pathway in rats with …
W Sun, Y Li, S Wei - Experimental and therapeutic …, 2018 - spandidos-publications.com
The present study aimed to investigate the effect and underlying mechanism of microRNA
(miR)‑4262 in the development of osteoarthritis (OA) in rats. Primary chondrocytes were …
(miR)‑4262 in the development of osteoarthritis (OA) in rats. Primary chondrocytes were …
[HTML][HTML] Mechanisms of immune response and cell death in ischemic stroke and their regulation by natural compounds
Z Gong, J Guo, B Liu, Y Guo, C Cheng, Y Jiang… - Frontiers in …, 2024 - frontiersin.org
Ischemic stroke (IS), which is the third foremost cause of disability and death worldwide, has
inflammation and cell death as its main pathological features. IS can lead to neuronal cell …
inflammation and cell death as its main pathological features. IS can lead to neuronal cell …
[HTML][HTML] Sympathectomy aggravates subchondral bone changes during osteoarthritis progression in mice without affecting cartilage degeneration or synovial …
Objective Osteoarthritis (OA) pathogenesis involves the interaction of articular cartilage with
surrounding tissues, which are innervated by tyrosine hydroxylase-positive (TH+) …
surrounding tissues, which are innervated by tyrosine hydroxylase-positive (TH+) …
[HTML][HTML] Microbial metabolite sodium butyrate attenuates cartilage degradation by restoring impaired autophagy and autophagic flux in osteoarthritis development
H Zhou, G Li, Y Wang, R Jiang, Y Li, H Wang… - Frontiers in …, 2021 - frontiersin.org
Osteoarthritis (OA) is a degenerative joint disease with multiple etiologies that affects
individuals worldwide. No effective interventions are currently available to reverse the …
individuals worldwide. No effective interventions are currently available to reverse the …