A number of receptor systems have been implicated to play an important role in the
development and progression of many human cancers. The epidermal growth factor (EGF) …

Ovarian steroid hormones play a critical role inregulating mammary gland growth and
development. Themammary gland sequentially acquires and cyclicallyexhibits proliferative …

Mice lacking the epidermal growth factor receptor (EGFR) develop epithelial defects and a
neurodegenerative disease and die within the first month of birth. By employing a …

Chemical mutagenesis in the mouse is a powerful approach for phenotype-driven genetics,
but questions remain about the efficiency with which new mutations ascertained by their …

Background A gap analysis was conducted to determine which areas of breast cancer
research, if targeted by researchers and funding bodies, could produce the greatest impact …

Janus kinase 2 (JAK2) and signal transducers and activators of transcription 5 (STAT5) are
involved in the proliferation, differentiation, and survival of mammary gland epithelial cells …

Transgenic mice expressing either the neu proto-oncogene or transforming growth factor
(TGF-α) in the mammary epithelium develop spontaneous focal mammary tumors that occur …

The complex process of lung formation is determined by the action of numerous genes that
influence cell commitment, differentiation, and proliferation. This review summarizes current …

Transforming growth factor‐α (TGFα), a member of the epidermal growth factor receptor
ligand family, has been implicated in the regeneration and transformation of liver. Our recent …

Expression of constitutively activated Akt in the mammary glands of transgenic mice results
in a delay in post-lactational involution. We now report precocious lipid accumulation in the …