Central sensitization (CS) is defined as an increased nociceptive responsiveness due to
sensitization of neurons in the central nervous system, usually the result of prolonged …

Objective The aim of this umbrella review with meta-meta-analysis was to assess the
effectiveness of orthopedic manual therapy in isolation on pain sensitization in patients with …

Exercise therapy is considered the best evidence-based approach for managing chronic
neck pain. However, the implementation of exercise therapy presents several challenges …

A spinal cord injury (SCI) causes changes in brain structure and brain function due to the
direct effects of nerve damage, secondary mechanisms, and long-term effects of the injury …

Introduction Transcranial magnetic stimulation (TMS) is a consolidated procedure for the
treatment of depression, with several meta-analyses demonstrating its efficacy. Theta-burst …

Purpose In OA studies, the focus often is on an index-joint; other affected joint sites are often
overlooked. In this thumb-base OA study, we documented the frequency of symptomatic non …

Central sensitization (CS) involves an amplification of neural processing within the central
nervous system that can result in widespread pain patterns and hypersensitivity to stimuli …

Background While preoperative psychological distress is known to predict risk for worse total
knee arthroplasty (TKA) outcomes, distress may be too broad and nonspecific a predictor in …

Although transcranial direct current stimulation (tDCS) is encouraging regarding clinical pain
intensity for individuals with knee osteoarthritis, very few studies have explored its impact on …

The pain pathomechanism of chronic low back pain (LBP) is complex and the available
diagnostic methods are insufficient. Patients present morphological changes in volume and …