Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic
ring are readily able to bind with a variety of enzymes and receptors in biological systems …

The emergence of new fungal pathogens makes the development of new antifungal drugs a
medical imperative that in recent years motivates the talents of numerous investigators …

Fungal conditions affect a multitude of people worldwide, leading to increased
hospitalization and mortality rates, and the need for novel antifungals is emerging with the …

Fungi, which can cause serious infections, results in more than 1.35 million deaths annually
throughout the world. Azole antifungal drugs which could inhibit the enzyme lanosterol 14α …

2, 3-Dihydroquinazolin-4 (1H)-one and tetrazole are a class of nitrogen-containing
heterocyclic compounds that play an important role in drug design and are an important part …

Tetrazoles are indispensable nitrogen containing heterocyclic scaffolds that offer a broad
spectrum of applications in various domains such as medicinal chemistry, high energy …

Candida species are the most common fungal pathogens infecting humans and can cause
severe illnesses in immunocompromised individuals. The increased resistance of Candida …

Candida albicans is a common opportunistic fungal pathogen that may cause nosocomial
fungal infections. The resistance of Candida albicans to traditional antifungal drugs has …

Fungal infections are still threatening human health due to resistance to existing drugs,
therefore, the design and development of novel antifungal agents is to be necessary and …

Voriconazole (VCZ) was the first approved triazole antifungal drug with 1-(1 H-1, 2, 4-triazol-
1-yl) butan-2-ol substructure. This drug showed a broad spectrum of activity, especially …