The anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are a
group of disorders involving severe, systemic, small-vessel vasculitis and are characterized …

B cells play a central role in the immunopathogenesis of glomerulonephritides and
transplant rejection. B cells secrete antibodies that contribute to tissue injury via multiple …

ANCA vasculitis has an associated autoimmune response that produces ANCAs that induce
distinct pathologic lesions. Pauci-immune necrotizing and crescentic GN is a frequent …

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) represents a group
of small vessel vasculitides characterized by granulomatous and neutrophilic tissue …

Antineutrophil cytoplasmic autoantibodies (ANCAs) are the probable cause of a distinct form
of vasculitis that can be accompanied by necrotizing granulomatosis. Clinical and …

Eosinophilic Granulomatosis with Polyangiitis (EGPA) is a rare multisystemic disease
classified both amongst hypereosinophilic disorders and ANCA-associated vasculitis …

Background Current guidelines advise that rituximab or cyclophosphamide should be used
for the treatment of organ-threatening disease in anti-neutrophil cytoplasm antibody (ANCA) …

B cells have a central role in many autoimmune diseases, including in those with renal
involvement, as well as in the immunological response to kidney transplantation. The …

Objective. ANCA-associated vasculitis (AAV) is characterized by a chronic relapsing course.
Rituximab (RTX) is an effective maintenance treatment; however, the long-term outcomes …

Results In the study, 172 patients (mean age= 60 years, 55% women, 57% myeloperoxidase–
ANCA) treated from April of 2006 to March of 2013 underwent continuous B-cell depletion …