Tolerance and innate immunity shape the development of postpartum uterine disease and the impact of endometritis in dairy cattle

IM Sheldon, JG Cronin… - Annual review of animal …, 2019 - annualreviews.org
Bacteria are ubiquitous in the bovine uterus after parturition, but 50 years ago, cows
tolerated these bacteria and few animals developed uterine disease. Now, up to 40% of …

Preventing postpartum uterine disease in dairy cattle depends on avoiding, tolerating and resisting pathogenic bacteria

IM Sheldon, PCC Molinari, TJR Ormsby, JJ Bromfield - Theriogenology, 2020 - Elsevier
Up to forty percent of dairy cows develop metritis or endometritis when pathogenic bacteria
infect the uterus after parturition. However, resilient cows remain healthy even when …

[HTML][HTML] Dynamics of uterine microbiota in postpartum dairy cows with clinical or subclinical endometritis

OB Pascottini, SJ Van Schyndel, JFW Spricigo… - Scientific reports, 2020 - nature.com
Our objectives were to describe and compare the uterine bacterial composition of
postpartum Holstein cows diagnosed as healthy (n= 8), subclinical endometritis (SCE; n= 8) …

Role for the mammalian female reproductive tract microbiome in pregnancy outcomes

BA Heil, DL Paccamonti… - Physiological …, 2019 - journals.physiology.org
Since the discovery of the microbiome in humans, it has been studied in many mammalian
species. Different microbiological communities with variable richness and diversity have …

[HTML][HTML] Catalpol ameliorates LPS-induced endometritis by inhibiting inflammation and TLR4/NF-κB signaling

H Zhang, Z Wu, Y Yang, A Shaukat, J Yang… - Journal of Zhejiang …, 2019 - ncbi.nlm.nih.gov
Catalpol is the main active ingredient of an extract from Radix rehmanniae, which in a
previous study showed a protective effect against various types of tissue injury. However, a …

General and comparative aspects of endometritis in domestic species: A review

OB Pascottini, C Aurich, G England… - … in Domestic Animals, 2023 - Wiley Online Library
Endometritis is a leading cause of sub‐and infertility in domestic animal species. The
healthy uterus is colonized by commensal bacteria, viruses and yeast/fungi that represent …

[HTML][HTML] Uterine microbiota of dairy cows with clinical and subclinical endometritis

ML Wang, MC Liu, J Xu, LG An, JF Wang… - Frontiers in …, 2018 - frontiersin.org
The objective of this study was to characterize the uterine microbiota of dairy cows with
clinical and subclinical endometritis and to identify the potential bacterial genera as well as …

[HTML][HTML] Symposium review: Selection for fertility in the modern dairy cow—Current status and future direction for genetic selection

MC Lucy - Journal of dairy science, 2019 - Elsevier
The establishment of pregnancy following insemination is the primary definition of fertility in
most dairy systems. Highly fertile cows establish pregnancy sooner after calving and require …

Ferulic acid inhibits bovine endometrial epithelial cells against LPS-induced inflammation via suppressing NK-κB and MAPK pathway

P Yin, Z Zhang, J Li, Y Shi, N Jin, W Zou, Q Gao… - Research in veterinary …, 2019 - Elsevier
Endometritis is one of the most common reproductive diseases caused by bacterial infection
in the cow. Ferulic acid is a major effective component extracted from Ligusticum wallichii …

[HTML][HTML] Effect of anti-inflammatory treatment on systemic inflammation, immune function, and endometrial health in postpartum dairy cows

OB Pascottini, SJ Van Schyndel, JFW Spricigo… - Scientific reports, 2020 - nature.com
Systemic inflammation (SI) is increasingly studied in several species because it may be
central in many metabolic disturbances and be a risk factor for clinical disease. This proof-of …