Premature infants are at high risk for developing bronchopulmonary dysplasia (BPD),
characterized by chronic inflammation and inhibition of lung development, which we have …

Extracellular vesicles (EVs) are heterogeneous cell-derived membranous vesicles which
carry a large diversity of molecules such as proteins and RNA species. They are now …

The proteins alpha-synuclein (αSyn) and leucine rich repeat kinase 2 (LRRK2) are both key
players in the pathogenesis of the neurodegenerative disorder Parkinson's disease (PD) …

Extracellular vesicles, including exosomes and microvesicles, play a fundamental role in the
activity of the nervous system, participating in signal transmission between neurons and …

Genetic variation in the leucine-rich repeat kinase 2 (LRRK2) gene is associated with risk of
familial and sporadic Parkinson's disease (PD). To support clinical development of LRRK2 …

Leucine-rich repeat kinase 2 (LRRK2) is a multidomain protein implicated in Parkinson
disease (PD); however, the molecular mechanism and mode of action of this protein remain …

Cancer stem cells (CSCs), functionally characterized by self-renewal and tumor-initiating
activity, contribute to decreased tumor immunogenicity, while fostering tumor growth and …

Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain protein, and LRRK2 mutants
are recognized risk factors for Parkinson's disease (PD). Although the precise mechanisms …

The science of gene therapy has experienced a controversial history. At first, the initial
concept that various disorders become curable by gene transferring was very exciting and …

Mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) gene are linked to autosomal
dominant Parkinson's disease (PD), and genetic variations at the LRRK2 locus are …