Exosomes are regarded as a promising biomarker for the noninvasive diagnosis and
treatment of diseases. The value of exosomes for medical research has promoted the search …

Extracellular vesicles (EVs) are released by all neural cells, including neurons,
oligodendrocytes, astrocytes, and microglia. The lack of adequate technology has not halted …

Parkinson's disease (PD) is a difficult disease to diagnose although it is the second most
common neurodegenerative disease. Recent studies show that exosome isolated from urine …

Missense mutations in the leucine-rich repeat kinase 2 (LRRK2) gene can cause late-onset
Parkinson disease (PD). LRRK2 mutations increase LRRK2 kinase activities that may …

14‐3‐3 proteins are abundantly expressed adaptor proteins that interact with a vast number
of binding partners to regulate their cellular localization and function. They regulate …

To explore how pathogenic mutations of the multidomain leucine-rich repeat kinase 2
(LRRK2) hijack its finely tuned activation process and drive Parkinson's disease (PD), we …

Extracellular vesicles (EVs) are involved in the development and progression of
neurodegenerative diseases, including Alzheimer's and Parkinson's disease. Moreover, EVs …

Diabetes represents a major threat to public health and the number of patients is increasing
alarmingly in the global scale. Particularly, the diabetic kidney disease (nephropathy, DN) …

Extracellular vesicles (EVs) are gaining increased importance in fundamental research as
key players in disease pathogenic mechanisms, but also in translational and clinical …

Parkinson's disease is a common neurodegenerative disease characterized by intracellular
aggregation of misfolded α-synuclein as a major pathological hallmark. Exosomes are cell …