Extracellular vesicles (EVs) have considerable potential as diagnostic, prognostic, and
therapeutic agents, in large part because molecular patterns on the EV surface betray the …

The Leucine rich repeat kinase 2 (LRRK2) gene is genetically and biochemically linked to
several diseases that involve innate immunity. LRRK2 protein is highly expressed in …

Background: Hypertension is a common cardiovascular disease that is related to genetic
and environmental factors, but its mechanisms remain unclear. DNA methylation, a classic …

Exosomes and microvesicles (EMVs) are lipid bilayer-enclosed structures released from
cells and participate in cell-to-cell communication via transport of biological molecules …

Exosomes play a key role in virus exocytosis and transmission. The exportin family is usually
responsible for cargo nucleocytoplasmic trafficking, and they are frequently found in …

Noninvasive and effortless diagnosis of Alzheimer's disease (AD) remains challenging. Here
we report the multiplexed profiling of extracellular vesicle (EV) surface proteins at the single …

Leucine-rich repeat kinase 2 (LRRK2) is a promising therapeutic target for the treatment of
Parkinson's disease (PD) and LRRK2 kinase inhibitors are currently being tested in early …

Proteases are important regulators of pulmonary remodeling and airway inflammation.
Recently, we have characterized the enzyme prolyl endopeptidase (PE), a serine peptidase …

The production of extracellular vesicles (EV) is a ubiquitous feature of eukaryotic cells but
pathological events can affect their formation and constituents. We sought to characterize …

Activating mutations in the leucine rich repeat protein kinase 2 (LRRK2) gene are the most
common cause of inherited Parkinson's disease (PD). LRRK2 is phosphorylated on a cluster …