COVID-19 and cardiovascular disease: from bench to bedside

MK Chung, DA Zidar, MR Bristow, SJ Cameron… - Circulation …, 2021 - Am Heart Assoc
A pandemic of historic impact, coronavirus disease 2019 (COVID-19) has potential
consequences on the cardiovascular health of millions of people who survive infection …

Developing therapeutic approaches for twenty-first-century emerging infectious viral diseases

RM Meganck, RS Baric - Nature medicine, 2021 - nature.com
The twenty-first century has already recorded more than ten major epidemic or pandemic
virus emergence events, including the ongoing and devastating coronavirus disease 2019 …

Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication

J Chu, C Xing, Y Du, T Duan, S Liu, P Zhang… - Nature …, 2021 - nature.com
Caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19 is a
virus-induced inflammatory disease of the airways and lungs that leads to severe multi …

Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19

C Mirabelli, JW Wotring, CJ Zhang… - Proceedings of the …, 2021 - National Acad Sciences
The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
and the associated disease COVID-19, requires therapeutic interventions that can be rapidly …

[HTML][HTML] Construction and applications of SARS-CoV-2 pseudoviruses: a mini review

M Chen, XE Zhang - International journal of biological sciences, 2021 - ncbi.nlm.nih.gov
The ongoing coronavirus disease 2019 pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has posed a serious threat to global public health …

Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products

CL He, LY Huang, K Wang, CJ Gu, J Hu… - Signal transduction and …, 2021 - nature.com
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) is a major public health issue. The spike (S) protein mutation …

Multidisciplinary approaches identify compounds that bind to human ACE2 or SARS-CoV-2 spike protein as candidates to block SARS-CoV-2–ACE2 receptor …

CJ Day, B Bailly, P Guillon, L Dirr, FEC Jen… - MBio, 2021 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged virus
that causes coronavirus infectious disease 2019 (COVID-19). SARS-CoV-2 spike protein …

[HTML][HTML] Application of pseudovirus system in the development of vaccine, antiviral-drugs, and neutralizing antibodies

Q Xiang, L Li, J Wu, M Tian, Y Fu - Microbiological Research, 2022 - Elsevier
Pseudoviruses are viral particles coated with a heterologous envelope protein, which
mediates the entry of pseudoviruses as efficiently as that of the live viruses possessing high …

Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein

L Wang, Y Wu, S Yao, H Ge, Y Zhu, K Chen… - Acta Pharmacologica …, 2022 - nature.com
An epidemic of pneumonia caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is spreading worldwide. SARS-CoV-2 relies on its spike protein to invade …

Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro

SM Fred, S Kuivanen, H Ugurlu… - Frontiers in …, 2022 - frontiersin.org
Repurposing of currently available drugs is a valuable strategy to tackle the consequences
of COVID-19. Recently, several studies have investigated the effect of psychoactive drugs on …