The broad spectrum of the mechanism of action of immune-boosting natural compounds as
well as the complex nature of the food matrices make researching the health benefits of …

A growing awareness of the mechanisms by which phytochemicals can influence upstream
endogenous cellular defence processes has led to intensified research into their potential …

An elaborate network of highly inducible proteins protects aerobic cells against the
cumulative damaging effects of reactive oxygen intermediates and toxic electrophiles, which …

The nuclear factor erythroid 2 related factor 2 (NRF2) is a key regulator of endogenous
inducible defense systems in the body. Under physiological conditions NRF2 is mainly …

Cancer onset and progression have been linked to oxidative stress by increasing DNA
mutations or inducing DNA damage, genome instability, and cell proliferation and therefore …

Cruciferous vegetables are a rich source of glucosinolates and their hydrolysis products,
including indoles and isothiocyanates, and high intake of cruciferous vegetables has been …

Oxidative stress is increased in systemic lupus erythematosus (SLE), and it contributes to
immune system dysregulation, abnormal activation and processing of cell-death signals …

Purpose: The existence of cancer stem cells (CSCs) in breast cancer has profound
implications for cancer prevention. In this study, we evaluated sulforaphane, a natural …

Acetylation of the [var epsilon]-amino group of a lysine residue was first discovered with
histones in 1968, but the responsible enzymes, histone acetyltransferases and …

Epigenetics refers to heritable changes that are not encoded in the DNA sequence itself, but
play an important role in the control of gene expression. In mammals, epigenetic …