Disturbance of cerebral redox homeostasis is the primary cause of human
neurodegenerative disorders, such as Parkinson's disease or Alzheimer's disease. Well …

Isoquinoline alkaloids are a large group of natural products in which 1, 2, 3, 4-
tetrahydroisoquinolines (THIQ) form an important class. THIQ based natural and synthetic …

Purslane (Portulaca oleraceae L.), a member of the Portulacaceae family, is widespread as
a weed and has been ranked as the eighth most common plant in the world. In order to …

Animal models are widely used to study antidepressant-like effect in rodents. However, it
should be mentioned that pharmacological models do not always take into account the …

Depression has been correlated with metabolic disorders, and the gut microbiota and its
metabolites have been reported to be key factors affecting metabolic disorders. Several …

Background: Neuropathy is a prevalent and debilitating complication of poorly managed
diabetes, contributing towards poor quality of life, amputation risk, and increased mortality …

The herbicide paraquat (PQ) is a strong redox agent that participates in the formation of
reactive oxygen species (ROS) and induces toxicity in the nigrostriatal dopaminergic system …

Parkinson's disease involves the progressive degeneration of dopaminergic neurons in the
substantia nigra. However, the etiology of the disease remains to be elucidated …

Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium
cation (MPP+) are selective dopaminergic neurotoxins producing Parkinsonism. MPTP is …

Recent research is leading to an ever-increasing range of investigative approaches whose
aim is to achieve effective neuroprotective or neurorestorative treatment for individuals …