Roles of sphingosine-1-phosphate signaling in cancer
P Wang, Y Yuan, W Lin, H Zhong, K Xu, X Qi - Cancer cell international, 2019 - Springer
The potent pleiotropic lipid mediator sphingosine-1-phosphate (S1P) participates in
numerous cellular processes, including angiogenesis and cell survival, proliferation, and …
numerous cellular processes, including angiogenesis and cell survival, proliferation, and …
BMPR2 Mutation and Metabolic Reprogramming in Pulmonary Arterial Hypertension
I Cuthbertson, NW Morrell, P Caruso - Circulation research, 2023 - Am Heart Assoc
Pulmonary arterial hypertension forms the first and most severe of the 5 categories of
pulmonary hypertension. Disease pathogenesis is driven by progressive remodeling of …
pulmonary hypertension. Disease pathogenesis is driven by progressive remodeling of …
N6-methyladenosine-modified circular RNA QSOX1 promotes colorectal cancer resistance to anti-CTLA-4 therapy through induction of intratumoral regulatory T cells
Z Liu, N Zheng, J Li, C Li, D Zheng, X Jiang, X Ge… - Drug Resistance …, 2022 - Elsevier
Background Colorectal cancer (CRC) is the 3rd most common cancer worldwide. CircRNAs
are promising novel biomarkers for CRC. T regulatory (Treg) cells express the immune …
are promising novel biomarkers for CRC. T regulatory (Treg) cells express the immune …
YAP mediates compensatory cardiac hypertrophy through aerobic glycolysis in response to pressure overload
T Kashihara, R Mukai, S Oka, P Zhai… - The Journal of …, 2022 - Am Soc Clin Investig
The heart utilizes multiple adaptive mechanisms to maintain pump function. Compensatory
cardiac hypertrophy reduces wall stress and oxygen consumption, thereby protecting the …
cardiac hypertrophy reduces wall stress and oxygen consumption, thereby protecting the …
LncRNA KCNQ1OT1 sponges miR-34c-5p to promote osteosarcoma growth via ALDOA enhanced aerobic glycolysis
Y Shen, J Xu, X Pan, Y Zhang, Y Weng, D Zhou… - Cell death & …, 2020 - nature.com
Metabolic switch from oxidative phosphorylation to aerobic glycolysis, which is also called
the Warburg effect, is a hallmark of osteosarcoma (OS) and leads to the enhancement of cell …
the Warburg effect, is a hallmark of osteosarcoma (OS) and leads to the enhancement of cell …
EGR2-mediated regulation of m6A reader IGF2BP proteins drive RCC tumorigenesis and metastasis via enhancing S1PR3 mRNA stabilization
Y Ying, X Ma, J Fang, S Chen, W Wang, J Li, H Xie… - Cell death & …, 2021 - nature.com
Emerging discoveries of dynamic and reversible N6-methyladenosine (m6A) modification on
RNA in mammals have revealed the key roles of the modification in human tumorigenesis …
RNA in mammals have revealed the key roles of the modification in human tumorigenesis …
[HTML][HTML] Sphingosine 1-phosphate receptor, a new therapeutic direction in different diseases
H Chen, J Wang, C Zhang, P Ding, S Tian… - Biomedicine & …, 2022 - Elsevier
Abstract Sphingosine 1-phosphate receptor (S1PR), as a kind of G protein-coupled receptor,
has five subtypes, including S1PR1, S1PR2, S1PR3, S1PR4, and S1PR5. Sphingosine 1 …
has five subtypes, including S1PR1, S1PR2, S1PR3, S1PR4, and S1PR5. Sphingosine 1 …
Hippo signaling pathway and respiratory diseases
W Tang, M Li, X Yangzhong, X Zhang, A Zu… - Cell Death …, 2022 - nature.com
The hippo signaling pathway is a highly conserved evolutionary signaling pathway that
plays an important role in regulating cell proliferation, organ size, tissue development, and …
plays an important role in regulating cell proliferation, organ size, tissue development, and …
Sphingosine kinase 1/S1P signaling contributes to pulmonary fibrosis by activating Hippo/YAP pathway and mitochondrial reactive oxygen species in lung fibroblasts
The sphingosine kinase 1 (SPHK1)/sphingosine–1–phosphate (S1P) signaling axis is
emerging as a key player in the development of idiopathic pulmonary fibrosis (IPF) and …
emerging as a key player in the development of idiopathic pulmonary fibrosis (IPF) and …
A potential role of YAP/TAZ in the interplay between metastasis and metabolic alterations
H Yamaguchi, GM Taouk - Frontiers in oncology, 2020 - frontiersin.org
Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ)
are the downstream effectors of the Hippo signaling pathway that play a crucial role in …
are the downstream effectors of the Hippo signaling pathway that play a crucial role in …