Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids
RNA–DNA hybrids are generated during transcription, DNA replication and DNA repair and
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …
Walking a tightrope: the complex balancing act of R-loops in genome stability
JR Brickner, JL Garzon, KA Cimprich - Molecular cell, 2022 - cell.com
Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …
R-loop-dependent promoter-proximal termination ensures genome stability
C Xu, C Li, J Chen, Y Xiong, Z Qiao, P Fan, C Li, S Ma… - Nature, 2023 - nature.com
The proper regulation of transcription is essential for maintaining genome integrity and
executing other downstream cellular functions,. Here we identify a stable association …
executing other downstream cellular functions,. Here we identify a stable association …
TERRA and RAD51AP1 promote alternative lengthening of telomeres through an R-to D-loop switch
Alternative lengthening of telomeres (ALT), a telomerase-independent process maintaining
telomeres, is mediated by break-induced replication (BIR). RAD52 promotes ALT by …
telomeres, is mediated by break-induced replication (BIR). RAD52 promotes ALT by …
Activation of homologous recombination in G1 preserves centromeric integrity
Centromeric integrity is key for proper chromosome segregation during cell division.
Centromeres have unique chromatin features that are essential for centromere …
Centromeres have unique chromatin features that are essential for centromere …
Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs
L Chen, Y Wang, J Lin, Z Song, Q Wang… - Nature …, 2022 - nature.com
Numerous RNAs are exported from the nucleus, abnormalities of which lead to cellular
complications and diseases. How thousands of circular RNAs (circRNAs) are exported from …
complications and diseases. How thousands of circular RNAs (circRNAs) are exported from …
Different SWI/SNF complexes coordinately promote R-loop-and RAD52-dependent transcription-coupled homologous recombination
C Davó-Martínez, A Helfricht… - Nucleic Acids …, 2023 - academic.oup.com
The SWI/SNF family of ATP-dependent chromatin remodeling complexes is implicated in
multiple DNA damage response mechanisms and frequently mutated in cancer. The BAF …
multiple DNA damage response mechanisms and frequently mutated in cancer. The BAF …
RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA
N Kaminski, AR Wondisford, Y Kwon, ML Lynskey… - Molecular cell, 2022 - cell.com
Alternative lengthening of telomeres (ALT) is a homology-directed repair (HDR) mechanism
of telomere elongation that controls proliferation in subsets of aggressive cancer. Recent …
of telomere elongation that controls proliferation in subsets of aggressive cancer. Recent …
Immediate-early, early, and late responses to DNA double stranded breaks
SR Kieffer, NF Lowndes - Frontiers in Genetics, 2022 - frontiersin.org
Loss or rearrangement of genetic information can result from incorrect responses to DNA
double strand breaks (DSBs). The cellular responses to DSBs encompass a range of highly …
double strand breaks (DSBs). The cellular responses to DSBs encompass a range of highly …
Non–B-form DNA tends to form in centromeric regions and has undergone changes in polyploid oat subgenomes
Q Liu, C Yi, Z Zhang, H Su, C Liu… - Proceedings of the …, 2023 - National Acad Sciences
Centromeres are the specialized regions of the chromosomes that direct faithful
chromosome segregation during cell division. Despite their functional conservation …
chromosome segregation during cell division. Despite their functional conservation …