The pathogenesis of rheumatoid arthritis

S Alivernini, GS Firestein, IB McInnes - Immunity, 2022 - cell.com
Significant recent progress in understanding rheumatoid arthritis (RA) pathogenesis has led
to improved treatment and quality of life. The introduction of targeted-biologic and-synthetic …

[HTML][HTML] Recent advances in understanding the pathogenesis of rheumatoid arthritis: new treatment strategies

AL Mueller, Z Payandeh, N Mohammadkhani… - Cells, 2021 - mdpi.com
Rheumatoid arthritis (RA) is considered a chronic systemic, multi-factorial, inflammatory, and
progressive autoimmune disease affecting many people worldwide. While patients show …

Seronegative autoimmune diseases: A challenging diagnosis

MV Lenti, CM Rossi, F Melazzini, M Gastaldi… - Autoimmunity …, 2022 - Elsevier
Autoimmune diseases (AID) are increasingly prevalent conditions which comprise more
than 100 distinct clinical entities that are responsible for a great disease burden worldwide …

[HTML][HTML] Autoantibodies in rheumatoid arthritis: historical background and novel findings

MV Sokolova, G Schett, U Steffen - Clinical reviews in allergy & …, 2022 - Springer
Autoantibodies represent a hallmark of rheumatoid arthritis (RA), with the rheumatoid factor
(RF) and antibodies against citrullinated proteins (ACPA) being the most acknowledged …

Autoantibodies to disease‐related proteins in joints as novel biomarkers for the diagnosis of rheumatoid arthritis

E Lönnblom, M Leu Agelii, O Sareila… - Arthritis & …, 2023 - Wiley Online Library
Objective This study was undertaken to develop and characterize a multiplex immunoassay
for detection of autoantibodies against peptides derived from proteins known to play a role in …

[HTML][HTML] Antibodies to a Citrullinated Porphyromonas gingivalis Epitope Are Increased in Early Rheumatoid Arthritis, and Can Be Produced by Gingival Tissue B Cells …

N Sherina, C de Vries, N Kharlamova, N Sippl… - Frontiers in …, 2022 - frontiersin.org
Based on the epidemiological link between periodontitis and rheumatoid arthritis (RA), and
the unique feature of the periodontal bacterium Porphyromonas gingivalis to citrullinate …

Crosstalk between B cells and neutrophils in rheumatoid arthritis

U Karmakar, S Vermeren - Immunology, 2021 - Wiley Online Library
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease without known cure
that primarily affects synovial joints. RA has a prevalence of approximately 1% of the …

[HTML][HTML] A comprehensive evaluation of the relationship between different IgG and IgA anti-modified protein autoantibodies in rheumatoid arthritis

C Grönwall, L Liljefors, H Bang, AH Hensvold… - Frontiers in …, 2021 - frontiersin.org
Seropositive rheumatoid arthritis (RA) is characterized by the presence of rheumatoid factor
(RF) and anti-citrullinated protein autoantibodies (ACPA) with different fine-specificities. Yet …

[HTML][HTML] Modifiable risk factors linked to the development of rheumatoid arthritis: evidence, immunological mechanisms and prevention

JA Maisha, HS El-Gabalawy, LJ O'Neil - Frontiers in Immunology, 2023 - frontiersin.org
Rheumatoid Arthritis (RA) is a common autoimmune disease that targets the synovial joints
leading to arthritis. Although the etiology of RA remains largely unknown, it is clear that …

[HTML][HTML] Rheumatoid arthritis sera antibodies to citrullinated collagen type II bind to joint cartilage

Q Li, Y Li, B Liang, R Xu, B Xu, E Lönnblom… - Arthritis Research & …, 2022 - Springer
Objective To investigate the occurrence and frequency of anti-citrullinated protein antibodies
(ACPA) to cyclic citrullinated type II collagen (COL2) epitope with a capacity to bind joint …