The microbiota–gut–brain axis in Huntington's disease: pathogenic mechanisms and therapeutic targets

MN Ekwudo, C Gubert, AJ Hannan - The FEBS Journal, 2024 - Wiley Online Library
Huntington's disease (HD) is a currently incurable neurogenerative disorder and is typically
characterized by progressive movement disorder (including chorea), cognitive deficits …

[HTML][HTML] The systemic effects of the enriched environment on the conditioned fear reaction

GA Grigoryan - Frontiers in Behavioral Neuroscience, 2023 - frontiersin.org
In this review, a hypothesis is proposed to explain the beneficial effect of an enriched
environment (EE) on the conditioned fear reaction (CFR) from the perspective of a functional …

[HTML][HTML] Enriched environment ameliorates propagation of tau pathology and improves cognition in rat model of tauopathy

V Mate, T Smolek, ZV Kazmerova, S Jadhav… - Frontiers in Aging …, 2022 - frontiersin.org
Introduction The typical symptoms of Alzheimer's disease (AD) are cognitive impairment,
disrupted spatial orientation, behavioral and psychiatric abnormalities, and later motor …

Environmental Deprivation Effects on Myelin Ultrastructure in Huntington Disease and Wildtype Mice

CI Radulescu, C Ferrari Bardile, M Garcia-Miralles… - Molecular …, 2023 - Springer
Environmental deprivation can have deleterious effects on adaptive myelination and
oligodendroglia function. Early stage Huntington disease (HD) is characterised by white …

Beyond the CAG triplet number: exploring potential predictors of delayed age of onset in Huntington's disease

S Di Tella, MRI Lo Monaco, M Petracca, P Zinzi… - Journal of …, 2022 - Springer
Objective Huntington's disease (HD) is a genetic neurodegenerative disease characterized
by cognitive, motor, and psychiatric dysfunction. It is caused by an expansion of the …

Sex-Specific Differences in the Progression of Huntington's Disease Symptoms: A National Study in China

S Chen, H Zhang, J Yu, X Cao, S Zhang, D Dong - Neuroepidemiology, 2024 - karger.com
Methods A nationwide cross-sectional study was conducted in Chinese individuals
diagnosed with HD. Symptom progression over time, encompassing physical, psychiatric …

[HTML][HTML] Sleep and circadian rhythm dysfunction in animal models of Huntington's disease

AJ Morton - Journal of Huntington's Disease, 2023 - content.iospress.com
Sleep and circadian disruption affects most individuals with Huntington's disease (HD) at
some stage in their lives. Sleep and circadian dysregulation are also present in many mouse …

Descripción de nuevos correlatos transcripcionales y de nuevas fuentes de biomarcadores en la enfermedad de Huntington

A Gallardo Orihuela - 2023 - rodin.uca.es
Esta tesis se ha centrado en mejorar las estrategias existentes de obtención de
biomarcadores con potencial valor pronóstico en la enfermedad de Huntington (EH), una …

Thrombospondin-1 (TSP-1) and Neuronal Plasticity: Implications in Down Syndrome

O Garcia, JA Villegas-Piña - Medical Research Archives, 2022 - esmed.org
Down syndrome is the most common genetic cause of intellectual disability. Nevertheless,
under certain stimulation processes, Down syndrome people can develop certain …

Environmental enrichment for stroke and traumatic brain injury: mechanisms and translational implications

L Nie, J He, J Wang, R Wang, L Huang… - Comprehensive …, 2011 - Wiley Online Library
Acquired brain injuries, such as ischemic stroke, intracerebral hemorrhage (ICH), and
traumatic brain injury (TBI), can cause severe neurologic damage and even death …