Neonatal cholestasis: emerging molecular diagnostics and potential novel therapeutics

AG Feldman, RJ Sokol - Nature reviews Gastroenterology & hepatology, 2019 - nature.com
Neonatal cholestasis is a group of rare disorders of impaired bile flow characterized by
conjugated hyperbilirubinaemia in the newborn and young infant. Neonatal cholestasis is …

[HTML][HTML] Alagille syndrome: diagnostic challenges and advances in management

MD Ayoub, BM Kamath - Diagnostics, 2020 - mdpi.com
Alagille syndrome (ALGS) is a multisystem disease characterized by cholestasis and bile
duct paucity on liver biopsy in addition to variable involvement of the heart, eyes, skeleton …

[PDF][PDF] Biliary atresia in children: update on disease mechanism, therapies, and patient outcomes

S Antala, SA Taylor - Clinics in liver disease, 2022 - Elsevier
Biliary atresia is a rare disease but remains the most common indication for pediatric liver
transplantation as there are no effective medical therapies to slow progression after …

Biliary atresia as a disease starting in utero: implications for treatment, diagnosis, and pathogenesis

KR Mysore, BL Shneider… - Journal of pediatric …, 2019 - journals.lww.com
Biliary atresia (BA) is the most common reason for pediatric liver transplant. BA's varied
presentation, natural history, and treatment with the Kasai portoenterostomy have been well …

Neonatal cholestasis: Updates on diagnostics, therapeutics, and prevention

AG Feldman, RJ Sokol - Neoreviews, 2021 - publications.aap.org
Cholestatic jaundice is a common presenting feature of hepatobiliary and/or metabolic
dysfunction in the newborn and young infant. Timely detection of cholestasis, followed by …

Diagnostic approach to neonatal and infantile cholestasis: a position paper by the SIGENP liver disease working group

G Ranucci, C Della Corte, D Alberti… - Digestive and Liver …, 2022 - Elsevier
Neonatal and infantile cholestasis (NIC) can represent the onset of a surgically correctable
disease and of a genetic or metabolic disorder worthy of medical treatment. Timely …

Diagnostic accuracy of two-dimensional shear wave elastography in detecting hepatic fibrosis in children with autoimmune hepatitis, biliary atresia and other chronic …

P Galina, E Alexopoulou, A Mentessidou, P Mirilas… - Pediatric …, 2021 - Springer
Background Although fibrosis is the main determinant of liver stiffness, other disease-related
factors usually disregarded in studies on liver elastography, such as inflammation and …

Alagille syndrome: current understanding of pathogenesis, and challenges in diagnosis and management

MD Ayoub, BM Kamath - Clinics in Liver Disease, 2022 - liver.theclinics.com
Alagille syndrome (ALGS) is the most common inherited cholestatic liver disease
encountered by pediatric hepatologists. Unlike most other causes of cholestasis, the …

Outcomes of biliary atresia in the Nordic countries–a multicenter study of 158 patients during 2005–2016

MP Pakarinen, LS Johansen, JF Svensson… - Journal of Pediatric …, 2018 - Elsevier
Background/purpose Biliary atresia is the most common reason for newborn cholestasis and
pediatric liver transplantation. Even after normalization of serum bilirubin after …

[HTML][HTML] Recent advances in understanding biliary atresia

A Wehrman, O Waisbourd-Zinman, RG Wells - F1000Research, 2019 - ncbi.nlm.nih.gov
Biliary atresia (BA) is a neonatal liver disease characterized by progressive obstruction and
fibrosis of the extrahepatic biliary tree as well as fibrosis and inflammation of the liver …