The autonomic nervous system and heart failure

VG Florea, JN Cohn - Circulation research, 2014 - Am Heart Assoc
The pathophysiology of heart failure (HF) is characterized by hemodynamic abnormalities
that result in neurohormonal activation and autonomic imbalance with increase in …

The neurohormonal hypothesis: a theory to explain the mechanism of disease progression in heart failure

M Packer - Journal of the American College of Cardiology, 1992 - Elsevier
Because physicians have traditionally considered heart failure to be a hemodynamic
disorder, they have described the syndrome of heart failure using hemodynamic concepts …

Relation between central and peripheral hemodynamics during exercise in patients with chronic heart failure. Muscle blood flow is reduced with maintenance of …

MJ Sullivan, JD Knight, MB Higginbotham, FR Cobb - Circulation, 1989 - Am Heart Assoc
We studied the central hemodynamic, leg blood flow, and metabolic responses to maximal
upright bicycle exercise in 30 patients with chronic heart failure attributable to severe left …

Depressed low frequency power of heart rate variability as an independent predictor of sudden death in chronic heart failure

M Galinier, A Pathak, J Fourcade… - European heart …, 2000 - academic.oup.com
Aims Identification of patients with chronic heart failure at risk for sudden death remains
difficult. We sought to assess the prognostic value for all-cause and sudden death of time …

Neurohormonal interactions and adaptations in congestive heart failure.

M Packer - Circulation, 1988 - Am Heart Assoc
When cardiac output falls after an insult t cardium, a number of neurohormonal mecd
activated to preserve circulatory homeo though originally viewed as a beneficial coI …

Clinical aspects of sympathetic activation and parasympathetic withdrawal in heart failure

JS Floras - Journal of the American College of Cardiology, 1993 - Elsevier
Proposed reflex mechanisms for generalized neurohumoral activation in heart failure
include decreased input from inhibitory baroreceptor afferent vessels and increased input …

Importance of hemodynamic response to therapy in predicting survival with ejection fraction≤ 20% secondary to ischemic or nonischemic dilated cardiomyopathy

LW Stevenson, JH Tillisch, M Hamilton, M Luu… - The American journal of …, 1990 - Elsevier
To identify patients with left ventricular ejection fractions≤ 20% who are likely to survive on
tailored medical therapy after referral to transplantation, this study of 152 patients addressed …

Pathophysiology of chronic heart failure.

M Packer - The Lancet, 1992 - elibrary.ru
Presents an overview of chronic heart failure. How heart failure has traditionally been
regarded; Focus on the pathophysiology of chronic heart failure due to systolic dysfunction …

Digoxin. A neurohormonal modulator in heart failure?

M Gheorghiade, D Ferguson - Circulation, 1991 - Am Heart Assoc
Clinical Use of Digitalis Glycosides The potential benefit of digoxin therapy in heart failure
patients is thought to be related to its positive inotropic effect that increases cardiac output …

Nonsteroidal anti-inflammatory drugs and heart failure

GS Bleumink, J Feenstra, MCJM Sturkenboom… - Drugs, 2003 - Springer
Heart failure constitutes an increasing public health problem because of the growing
incidence and prevalence, poor prognosis and high hospital (re) admission rates …