The hygiene hypothesis postulates that an environment with a high incidence of infectious
diseases protects against allergic and autoimmune diseases, whereas hygienic …

Vitamin D system comprises hormone precursors, active metabolites, carriers, enzymes, and
receptors involved in genomic and non-genomic effects. In addition to classical bone-related …

Multiple sclerosis (MS) is a commonly occurring inflammatory and demyelinating
neurological disease. It has been considered to be an autoimmune disorder mediated by …

Genome-wide association studies (GWAS) testing several hundred thousand SNPs have
been performed in multiple sclerosis (MS) and other complex diseases. Typically, the …

Microglia are the resident immune cells that constantly survey the central nervous system.
They can adapt to their environment and respond to injury or insult by altering their …

The prevalence of multiple sclerosis (MS) increases significantly with decreasing UV B light
exposure, possibly reflecting a protective effect of vitamin D 3. Consistent with this theory …

Microglia participate in all phases of the multiple sclerosis (MS) disease process. As
members of the innate immune system, these cells have evolved to respond to …

Multiple sclerosis (MS) is a complex neurodegenerative disease whose pathogenesis
involves genetic and environmental risk factors leading to an aberrant, neuroantigen …

Multiple sclerosis (MS) is a T-cell-mediated disease of the central nervous system,
characterized by damage to myelin and axons, resulting in progressive neurological …

Multiple sclerosis is a clinically heterogeneous demyelinating disease and an important
cause of acquired neurological disability. An underlying complex genetic susceptibility plays …