Immune ageing at single-cell resolution
Ageing leads to profound alterations in the immune system and increases susceptibility to
some chronic, infectious and autoimmune diseases. In recent years, widespread application …
some chronic, infectious and autoimmune diseases. In recent years, widespread application …
The ins and outs of innate and adaptive type 2 immunity
AB Molofsky, RM Locksley - Immunity, 2023 - cell.com
Type 2 immunity is orchestrated by a canonical group of cytokines primarily produced by
innate lymphoid cells, group 2, and their adaptive counterparts, CD4+ helper type 2 cells …
innate lymphoid cells, group 2, and their adaptive counterparts, CD4+ helper type 2 cells …
Mucosal-associated invariant T cells restrict reactive oxidative damage and preserve meningeal barrier integrity and cognitive function
Increasing evidence indicates close interaction between immune cells and the brain,
revising the traditional view of the immune privilege of the brain. However, the specific …
revising the traditional view of the immune privilege of the brain. However, the specific …
Immune dynamics in the CNS and its barriers during homeostasis and disease
MW Buckley, DB McGavern - Immunological reviews, 2022 - Wiley Online Library
The central nervous system (CNS) has historically been viewed as an immunologically
privileged site, but recent studies have uncovered a vast landscape of immune cells that …
privileged site, but recent studies have uncovered a vast landscape of immune cells that …
IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2
Aging impairs the integrated immunometabolic responses, which have evolved to maintain
core body temperature in homeotherms to survive cold stress, infections, and dietary …
core body temperature in homeotherms to survive cold stress, infections, and dietary …
Early-to-mid stage idiopathic Parkinson's disease shows enhanced cytotoxicity and differentiation in CD8 T-cells in females
CM Capelle, S Ciré, F Hedin, M Hansen… - Nature …, 2023 - nature.com
Neuroinflammation in the brain contributes to the pathogenesis of Parkinson's disease (PD),
but the potential dysregulation of peripheral immunity has not been systematically …
but the potential dysregulation of peripheral immunity has not been systematically …
Immunosenescence is both functional/adaptive and dysfunctional/maladaptive
Alterations in the immune system with aging are considered to underlie many age-related
diseases. However, many elderly individuals remain healthy until even a very advanced …
diseases. However, many elderly individuals remain healthy until even a very advanced …
Current views on meningeal lymphatics and immunity in aging and Alzheimer's disease
S Rego, G Sanchez, S Da Mesquita - Molecular neurodegeneration, 2023 - Springer
Alzheimer's disease (AD) is an aging-related form of dementia associated with the
accumulation of pathological aggregates of amyloid beta and neurofibrillary tangles in the …
accumulation of pathological aggregates of amyloid beta and neurofibrillary tangles in the …
The therapeutic potential of carnosine/anserine supplementation against cognitive decline: A systematic review with meta-analysis
Carnosine is a natural occurring endogenous dipeptide that was proposed as an anti-aging
agent more than 20 years ago. Carnosine can be found at low millimolar concentrations at …
agent more than 20 years ago. Carnosine can be found at low millimolar concentrations at …
Assessing causal relationship between circulating cytokines and age-related neurodegenerative diseases: a bidirectional two-sample Mendelian randomization …
Z Yin, J Chen, M Xia, X Zhang, Y Li, Z Chen, Q Bao… - Scientific Reports, 2023 - nature.com
Numerous studies have reported that circulating cytokines (CCs) are linked to age-related
neurodegenerative diseases (ANDDs); however, there is a lack of systematic investigation …
neurodegenerative diseases (ANDDs); however, there is a lack of systematic investigation …