Neuroimmune crosstalk in the pathophysiology of hypertension

L Calvillo, MM Gironacci, L Crotti, PL Meroni… - Nature reviews …, 2019 - nature.com
Hypertension is an important risk factor for cardiovascular morbidity and mortality and for
events such as myocardial infarction, stroke, heart failure and chronic kidney disease and is …

Central nervous system pharmacology of neuropeptide Y

JG Wettstein, B Earley, JL Junien - Pharmacology & therapeutics, 1995 - Elsevier
Neuropeptide Y (NPY) is a 36-amino acid peptide belonging to the pancreatic polypeptide
family that has marked and diverse biological activity across species. NPY originally was …

Augmented resting sympathetic activity in awake patients with obstructive sleep apnea

JT Carlson, J Hedner, M Elam, H Ejnell, J Sellgren… - Chest, 1993 - Elsevier
Muscle nerve sympathetic activity (MSA) was recorded during wakefulness in 11 patients
with obstructive sleep apnea (OSA) and in 9 sex-and age-matched healthy control subjects …

Increase of sympathetic outflow measured by neuropeptide Y and decrease of the hypothalamic-pituitary-adrenal axis tone in patients with systemic lupus …

P Härle, RH Straub, R Wiest, A Mayer… - Annals of the …, 2006 - ard.bmj.com
Objective: To study in parallel the outflow of the sympathetic nervous system (SNS) and the
hypothalamic-pituitary adrenal (HPA) axis tone in systemic lupus erythematosus (SLE) and …

The role of neuropeptide Y in the pathophysiology of atherosclerotic cardiovascular disease

P Zhu, W Sun, C Zhang, Z Song, S Lin - International journal of cardiology, 2016 - Elsevier
With average life expectancy rising greatly, the incidence rate of arteriosclerotic
cardiovascular disease (ASCVD) has significantly increased. The heart disease has now …

Peripheral cardiac sympathetic hyperactivity in cardiovascular disease: role of neuropeptides

J Shanks, N Herring - American Journal of Physiology …, 2013 - journals.physiology.org
High levels of sympathetic drive in several cardiovascular diseases including
postmyocardial infarction, chronic congestive heart failure and hypertension are reinforced …

Low plasma concentrations of VIP and elevated levels of other neuropeptides during exacerbations of asthma

LO Cardell, R Uddman… - European Respiratory …, 1994 - Eur Respiratory Soc
Neuropeptides in the lung occur in neurons, neuroendocrine and inflammatory cells. Their
widespread distribution and physiological effects suggest that they may play important roles …

Neuropeptide Y stimulates proliferation of human vascular smooth muscle cells: cooperation with noradrenaline and ATP

D Erlinge, J Brunkwall, L Edvinsson - Regulatory peptides, 1994 - Elsevier
Since the sympathetic nervous system has been shown to exert a trophic influence on
vascular smooth muscle cells (SMC), we studied the growth regulating effects of …

Plasma neuropeptide Y in patients with major depressive disorder

H Hashimoto, H Onishi, S Koide, K Toshihiro… - Neuroscience …, 1996 - Elsevier
It has been suggested that neuropeptide Y (NPY) is involved in the pathophysiology of
depression. Plasma peptide-rich fraction from patients with major depressive disorder and …

NPY and cardiac diseases

BJ McDermott, D Bell - Current topics in medicinal chemistry, 2007 - ingentaconnect.com
Hypertension-induced left ventricular hypertrophy (LVH), along with ischemic heart disease,
result in LV remodeling as part of a continuum that often leads to congestive heart failure …