Chemical compounds that interfere with microtubules such as the vinca alkaloids and
taxanes are important chemotherapeutic agents for the treatment of cancer. As our …

Traumatic brain injury (TBI) is linked to several pathologies for which there is a lack of
understanding of disease mechanisms and therapeutic strategies. To elucidate injury …

Cerebral cavernous malformation (CCM) is a common vascular dysplasia that affects both
systemic and central nervous system blood vessels. Loss of function mutations in the CCM2 …

Inhibition of ERK-MAPK signaling by expression of dominant-negative MEK1 in the tumor
vasculature suppresses angiogenesis and tumor growth. In an organotypic tissue culture …

We have previously described the only reported case of human proprotein convertase 1
(PC1) deficiency, in a female (Subject A) with obesity, hypogonadism, hypoadrenalism, and …

Activation of latent TGF-β by the αvβ6 integrin is a critical step in the development of acute
lung injury. However, the mechanism by which αvβ6-mediated TGF-β activation is regulated …

Endothelial tubulogenesis is a crucial step in the formation of functional blood vessels
during angiogenesis and vasculogenesis. Here, we use in vivo imaging of living zebrafish …

Here we show that endothelial cells (EC) require matrix type 1-metalloproteinase (MT1-
MMP) for the formation of lumens and tube networks in 3-dimensional (3D) collagen …

Many studies reveal a fundamental role for extracellular matrix-mediated signaling through
integrins and Rho GTPases as well as matrix metalloproteinases (MMPs) in the molecular …

Microtubule-binding drugs (MBD) are widely used in cancer chemotherapy and also have
clinically relevant antiangiogenic and vascular-disrupting properties. These antivascular …