Atopic dermatitis is a chronic inflammatory skin disease with a complex pathogenesis, where
changes in skin barrier and imbalance of the immune system are relevant factors. The skin …

Tight junctions are important for skin barrier function. The tight junction protein claudin 1
(Cldn-1) has been reported to be down-regulated in nonlesional skin of atopic dermatitis …

Recent epidemiological studies found the US prevalence of atopic dermatitis in adults to be
approximately 7%. In particular, one in four adults with atopic dermatitis report adult onset of …

Inflammation of the skin is found after various external stimuli, eg, UV radiation, allergen
uptake, microbial challenge, or contact with irritants, as well as due to intrinsic, not always …

WWW. CUTIS. COM an essential function in the skin barrier through its differential cleavage
and the breakdown and release of natural moisturizing factor. 16 Filaggrin gene mutations …

Bicellular tight junctions (TJs) are intercellular junctions comprised of a variety of
transmembrane proteins including occludin, claudins, and junctional adhesion molecules …

Psoriasis is a chronic skin disease caused by the excessive secretion of inflammatory
cytokines. Available therapeutic options include biologic drugs such as tumor necrosis factor …

Abstract Background Tight junctions (TJs) have important roles in skin barrier function. The
TJ protein claudin-1 (CLDN1) is decreased in atopic dermatitis (AD). However, little is known …

Morinda citrifolia, a fruit generally known as “Noni”, has been traditionally used in parts of
East Asia to relieve inflammatory diseases. Although several studies using noni have been …

BACKGROUND: Atopic dermatitis is a highly prevalent inflammatory and pruritic dermatosis
with a multifactorial etiology, which includes skin barrier defects, immune dysfunction, and …