Expression of the filaggrin gene in umbilical cord blood predicts eczema risk in infancy: a birth cohort study

AH Ziyab, S Ewart, GA Lockett, H Zhang… - Clinical & …, 2017 - Wiley Online Library
Background Filaggrin gene (FLG) expression, particularly in the skin, has been linked to the
development of the skin barrier and is associated with eczema risk. However, knowledge as …

The pathogenetic role of Th17 immune response in atopic dermatitis

E David, T Czarnowicki - Current Opinion in Allergy and Clinical …, 2023 - journals.lww.com
The well established role of IL-17 in autoimmune disorders hints for its possible participation
in AD disease pathogenesis. Subsequent investigations are needed to assess whether the …

Oral treatment with Aloe polysaccharide ameliorates ovalbumin‐induced atopic dermatitis by restoring tight junctions in skin

K Na, E Lkhagva‐Yondon, M Kim… - Scandinavian …, 2020 - Wiley Online Library
Atopic dermatitis (AD) is a chronic inflammatory skin disease. A hallmark of AD is dry itchy
skin that results from defects in the epidermal barrier function. Aloe vera is used widely to …

Single‐cell RNA sequencing reveals 2D cytokine assay can model atopic dermatitis more accurately than immune‐competent 3D setup

B Al, S Traidl, N Holzscheck… - Experimental …, 2024 - Wiley Online Library
Modelling atopic dermatitis (AD) in vitro is paramount to understand the disease
pathophysiology and identify novel treatments. Previous studies have shown that the Th2 …

Mesenchymal stem cells profile in adult atopic dermatitis and effect of IL4-IL13 inflammatory pathway inhibition In vivo: Prospective case-control study

A Campanati, M Orciani, A Marani… - journal of clinical …, 2022 - mdpi.com
Atopic dermatitis (AD) is an inflammatory disease that typically begins in childhood and may
persist into adulthood, becoming a lifelong condition. The major inflammatory mediators of …

CLDN1 Arg81His founder variant causes ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis (ILVASC) syndrome in Moroccan Jews

M Eskin‐Schwartz, V Dolgin, E Didkovsky… - Clinical …, 2024 - Wiley Online Library
Neonatal ichthyosis and sclerosing cholangitis syndrome (NISCH), also known as
ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis (ILVASC), is an …

CYT387, a novel JAK2 inhibitor, suppresses IL-13-induced epidermal barrier dysfunction via miR-143 targeting IL-13Rα1 and STAT3

Y Zu, XF Chen, Q Li, ST Zhang - Biochemical Genetics, 2021 - Springer
Atopic dermatitis (AD) is a chronic inflammatory skin disease influencing not only children
but also adults. It is well-known that AD has a complex pathogenesis without effective …

[PDF][PDF] Перспективные направления в терапии атопического дерматита

АА Кубанова, АА Кубанов, АЭ Карамова… - Вестн дерматол, 2017 - core.ac.uk
Атопический дерматит–хроническое рецидивирующее воспалительное заболевание,
обусловленное в том числе нарушениями барьерной функции кожи и патологической …

Stabilization of microtubules restores barrier function after cytokine-induced defects in reconstructed human epidermis

CY Hsu, N Lecland, V Pendaries, C Viodé… - Journal of …, 2018 - Elsevier
Background A variety of human skin disorders is characterized by defects in the epidermal
barrier, leading to dehydration, itchiness, and rashes. Previously published literature …

Characterization of skin barrier defects using infrared spectroscopy in patients with atopic dermatitis

SF Williams, H Wan, J Chittock, K Brown… - Clinical and …, 2024 - academic.oup.com
Background Atopic dermatitis (AD) is characterized by skin barrier defects that are often
measured by biophysical tools that observe the functional properties of the stratum corneum …