Epilepsy is a chronic neurological disease characterized by an enduring propensity for
generation of seizures. The pathogenic processes of seizure generation and recurrence are …

Nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3
(NLRP3) is an intracellular innate immune receptor that recognizes a diverse range of …

Extracellular adenine nucleotides play important roles in cell–cell communication and tissue
homeostasis. High concentrations of extracellular ATP released by dying cells are sensed …

Cytokines exert profound effects on the progression of hematopoietic malignancies such as
acute myeloid leukemia (AML). Critical roles of cytokines in the context of inflammation have …

The multifunctional protein, voltage-dependent anion channel 1 (VDAC1), is located on the
mitochondrial outer membrane. It is a pivotal protein that maintains mitochondrial function to …

Pyroptosis is a pro-inflammatory type of regulated cell death (RCD) characterized by
gasdermin protein-mediated membrane pore formation, cell swelling, and rapid lysis …

Psoriasis (PS) is a skin disease with autoimmune features mediated by immune cells, which
typically presents inflammatory erythematous plaques, and is associated with many …

Interleukin (IL)-38, a newly discovered IL-1 family cytokine, is expressed in several tissues
and secreted by various cells. IL-38 has recently been reported to exert an anti-inflammatory …

Brain microglia cells are responsible for recognizing foreign bodies and act by activating
other immune cells. Microglia react against infectious agents that cross the blood-brain …

Background and Aims: Chronic inflammation induces liver fibrosis, cirrhosis and potentially
liver cancer. Kupffer cells modulate hepatic stellate cells by secreting immunologically active …