Tendon injuries disrupt the balance between stability and mobility, causing compromised
functions and disabilities. The regeneration of mature, functional tendons remains a clinical …

The metastatic process is highly inefficient—very few of the many cells that migrate from the
primary tumour successfully colonize distant sites. One proposed mechanism to explain this …

Periostin is a multifunctional extracellular matrix protein involved in various inflammatory
diseases and tumor metastasis; however, evidence regarding whether and how periostin …

Objective Periostin (POSTN) overexpression observed in various cancer types is correlated
with metastasis and tumor progression. However, its effect on the crosstalk between ovarian …

Akt/PKB is a serine/threonine protein kinase that functions as a critical regulator of cell
survival and proliferation. Akt/PKB family comprises three highly homologous members …

Metastatic complications are responsible for more than 90% of cancer-related deaths. The
progression from an isolated tumor to disseminated metastatic disease is a multistep …

Following the induction of DNA damage, a prominent route of cell inactivation is apoptosis.
During the last ten years, specific DNA lesions that trigger apoptosis have been identified …

The term matricellular proteins describes a family of structurally unrelated extracellular
macromolecules that, unlike structural matrix proteins, do not play a primary role in tissue …

Keloids are considered as benign fibroproliferative skin tumors growing beyond the site of
the original dermal injury. Although traditionally viewed as a form of skin scarring, keloids …

During tumor development, tumor cells constantly communicate with the surrounding
microenvironment through both biochemical and biophysical cues. In particular, the tumor …