Myocardial and vascular endothelial tissues have receptors for thyroid hormones and are
sensitive to changes in the concentrations of circulating thyroid hormones. The importance …

There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …

Mitochondria undergo fragmentation in response to electron transport chain (ETC) poisons
and mitochondrial DNA–linked disease mutations, yet how these stimuli mechanistically …

Background: Heart failure (HF) is currently classified according to left ventricular ejection
fraction (LVEF); however, the prognostic value of LVEF is controversial. Myocardial strain is …

Muscle contraction depends on release of Ca2+ from the sarcoplasmic reticulum (SR) and
reuptake by the Ca2+ adenosine triphosphatase SERCA. We discovered a putative muscle …

Functional micropeptides can be concealed within RNAs that appear to be noncoding. We
discovered a conserved micropeptide, which we named myoregulin (MLN), encoded by a …

The onset of heart failure is typically preceded by cardiac hypertrophy, a response of the
heart to increased workload, a cardiac insult such as a heart attack or genetic mutation …

Cellular Ca 2+ homeostasis is maintained through the integrated and coordinated function
of Ca 2+ transport molecules, Ca 2+ buffers and sensors. These molecules are associated …

Fibroblasts comprise the largest cell population in the myocardium. In heart disease, the
number of fibroblasts is increased either by replication of the resident myocardial fibroblasts …

Cardiovascular disease is the primary cause of morbidity and mortality among the diabetic
population. Both experimental and clinical evidence suggest that diabetic subjects are …