Withaferin A: From ayurvedic folk medicine to preclinical anti-cancer drug

B Hassannia, E Logie, P Vandenabeele… - Biochemical …, 2020 - Elsevier
Despite the recent successes of targeted cancer immuno-therapies, drug resistance and
disease relapse remain a huge burden in cancer patient treatment. This has fueled renewed …

Recent advances in triterpenoid pathway elucidation and engineering

S Dinday, S Ghosh - Biotechnology Advances, 2023 - Elsevier
Triterpenoids are among the most assorted class of specialized metabolites found in all the
taxa of living organisms. Triterpenoids are the leading active ingredients sourced from plant …

Recent trends and advances of RNA interference (RNAi) to improve agricultural crops and enhance their resilience to biotic and abiotic stresses

JK Bharathi, R Anandan, LK Benjamin… - Plant Physiology and …, 2023 - Elsevier
Over the last two decades, significant advances have been made using genetic engineering
technology to modify genes from various exotic origins and introduce them into plants to …

Exploring nature's bounty: identification of Withania somnifera as a promising source of therapeutic agents against COVID-19 by virtual screening and in silico …

A Srivastava, S Siddiqui, R Ahmad… - Journal of …, 2022 - Taylor & Francis
Coronaviruses are etiological agents of extreme human and animal infection resulting in
abnormalities primarily in the respiratory tract. Presently, there is no defined COVID-19 …

Enhancement of phytosterol and triterpenoid production in plant hairy root cultures—simultaneous stimulation or competition?

A Rogowska, A Szakiel - Plants, 2021 - mdpi.com
Plant in vitro cultures, including hairy roots, can be applied for controlled production of
valuable natural products, such as triterpenoids and sterols. These compounds originate …

Endophytes of Withania somnifera modulate in planta content and the site of withanolide biosynthesis

SS Pandey, S Singh, H Pandey, M Srivastava, T Ray… - Scientific reports, 2018 - nature.com
Tissue specific biosynthesis of secondary metabolites is a distinguished feature of medicinal
plants. Withania somnifera, source of pharmaceutically important withanolides …

Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal

S Kumar, SO Mathew, RP Aharwal, HS Tulli… - Pharmaceuticals, 2023 - mdpi.com
Cancer represents the second most deadly disease and one of the most important public
health concerns worldwide. Surgery, chemotherapy, radiation therapy, and immune therapy …

[HTML][HTML] The immunomodulatory role of Withania somnifera (L.) dunal in inflammatory diseases

HH Alanazi, E Elfaki - Frontiers in Pharmacology, 2023 - frontiersin.org
Withania somnifera (L.) Dunal (Solanaceae)(also known as Ashwagandha) is a botanical
drug that has been used for centuries to treat many chronic diseases like high blood …

Yeast as a promising heterologous host for steroid bioproduction

S Xu, Y Li - Journal of Industrial Microbiology & Biotechnology …, 2020 - academic.oup.com
With the rapid development of synthetic biology and metabolic engineering technologies,
yeast has been generally considered as promising hosts for the bioproduction of secondary …

In perspective: Potential medicinal plant resources of Kashmir Himalayas, their domestication and cultivation for commercial exploitation

SM Jeelani, GA Rather, A Sharma, SK Lattoo - Journal of applied research …, 2018 - Elsevier
The rich biodiversity of India and its extensive use since millennia for overall healthcare
system has found renewed interest due to recent advances in modern biology …