The druggable genome is limited by structural features that can be targeted by small
molecules in disease-relevant proteins. While orthosteric and allosteric protein modulators …

There is growing evidence that lactate can have a wide range of biological impacts in
addition to being a waste product of metabolism. Because of the Warburg effect, tumors …

KEAP1 (Kelch-like ECH-associated protein), a cytoplasmic repressor of the oxidative stress
responsive transcription factor Nuclear factor erythroid 2-related factor 2 (NRF2), senses the …

The pyruvate kinase M2 (PKM2) can significantly affect the differentiation of Th17 and Treg
cells; thus, it is considered a promising target for UC therapy. Herein, five series of …

Background Therapeutic approaches based on glycolysis and energy metabolism of tumor
cells are new promising strategies for the treatment of cancer. Currently, researches on the …

Natural products serve as a valuable reservoir of anticancer agents. Chinese poplar propolis
(CP) has exhibited remarkable antitumor activities, yet its precise mechanisms of action …

Abstract Pyruvate kinase M2 (PKM2) is a key glycolytic enzyme that regulates proliferating
cell metabolism. The role of PKM2 in common diseases has been well established, but its …

In recent years, advancements in deep learning techniques have significantly expanded the
structural coverage of the human proteome. GalaxySagittarius-AF translates these …

Cancer cells need to carefully regulate their metabolism to keep them growing and dividing
under the influence of different nutrients and oxygen levels. Muscle isoform 2 of pyruvate …

Alterations in cancer metabolic pathways open up an opportunity for targeted and effective
elimination of tumor cells. Pyruvate kinase M2 (PKM2) is predominantly expressed in …