Racial and ethnic differences in response to medicines: towards individualized pharmaceutical treatment.

VJ Burroughs, RW Maxey, RA Levy - Journal of the National …, 2002 - ncbi.nlm.nih.gov
It is now well documented that substantial disparities exist in the quality and quantity of
medical care received by minority Americans, especially those of African, Asian and …

Effects of β-blockers on glucose and lipid metabolism

VA Fonseca - Current medical research and opinion, 2010 - Taylor & Francis
Background: Activation of the sympathetic nervous system (SNS) has been linked to
hypertension. Beta-blockers, which decrease SNS activation via β-adrenergic receptor …

The vasodilatory beta-blockers

ME Pedersen, JR Cockcroft - Current hypertension reports, 2007 - Springer
Although well established in treating hypertension and cardiovascular (CV) disease, clinical
trial data suggest that β-blockers (eg, atenolol) may be less effective than other …

Pathophysiology and treatment implications of hypertension in the African-American population

M Rahman, JG Douglas… - … and Metabolism Clinics, 1997 - endo.theclinics.com
Hypertension is a leading cause of morbidity and mortality in the United States. Associated
with the long-term consequences of strokes, heart disease, and renal failure, hypertension …

Labetalol: a reappraisal of its pharmacology, pharmacokinetics and therapeutic use in hypertension and ischaemic heart disease

KL Goa, P Benfield, EM Sorkin - Drugs, 1989 - Springer
Since labetalol was first reviewed in the Journal (1978), its scope of therapeutic use has
expanded and become better defined. Labetalol is an adrenoceptor blocking drug with …

Hypertensive cardiovascular disease in African Americans

RK Wali, MR Weir - Current hypertension reports, 1999 - Springer
Hypertension is the most common public health challenge in the United States because of
its prevalence and associated increase in comorbid cardiovascular diseases 1. Yearly …

Use of β‐adrenergic receptor blockers in blacks

LM Prisant, GA Mensah - The Journal of Clinical Pharmacology, 1996 - Wiley Online Library
Beta adrenergic receptor blockers (β‐blockers) are an important class of drugs in the
management of patients with cardiovascular diseases. These drugs have been shown to …

Pharmacologic management of systemic hypertension in blacks

MR Weir, E Saunders - The American Journal of Cardiology, 1988 - Elsevier
This article contrasts the characteristics of essential hypertension found in the black
population with that seen in the nonblack population. Socioeconomic and pathophysiologic …

[PDF][PDF] Gender, ethnicity, and genes in cardiovascular disease. Part 2: implications for pharmacotherapy

BM Schaefer, V Caracciolo, WH Frishman… - Heart Disease-a …, 2003 - academia.edu
Women are underrepresented in clinical trials. Lower doses of beta-blockers are required for
Southeast Asians. ACE and ARB's are teratogenic in the second trimester. Torsades de …

Role of vasobilation in the antihypertensive and antianginal effects of labetalol: implications for therapy of combined hypertension and angina

LH Opie - Cardiovascular Drugs and Therapy, 1988 - Springer
Beta-adrenergic blockade is established therapy in the management of both hypertension
and angina pectoris. This review evaluates the use of combined alpha-adrenergic and beta …