Endocrine cells within the pancreatic islets of Langerhans are heterogeneous in terms of
transcriptional profile, protein expression and the regulation of hormone release. Even …

The pancreas is an endoderm-derived glandular organ that participates in the regulation of
systemic glucose metabolism and food digestion through the function of its endocrine and …

Cell-cell communication plays a pivotal role in coordination and function of biological
systems. Three-dimensional (3D) spheroids provide venues to explore cellular …

Human pluripotent stem cell (hPSC)-derived islet cells provide promising resources for
diabetes studies, cell replacement treatment and drug screening. Recently, hPSC-derived …

Glucose homeostasis is controlled by endocrine pancreatic cells, and any pancreatic
disturbance can result in diabetes. Because 8% to 12% of diabetic pregnant women present …

Although β-cell heterogeneity was discovered more than 50 years ago, the underlying
principles have been explored only during the past decade. Islet-cell heterogeneity arises …

The pancreatic islet secretes the hormones insulin and glucagon to regulate glucose
metabolism. To generate an adequate secretory response, islet endocrine cells must receive …

Sympathetic neurons depend on target-derived neurotrophic cues to control their survival
and growth. However, whether sympathetic innervation contributes reciprocally to the …

Background Diabetes mellitus is a common metabolic disorder characterized by dysfunction
of insulin-secreting pancreatic beta-cells. MicroRNAs are important regulators of beta-cell …

Diabetes mellitus (DM) is one of the most prevalent metabolic disorders. In order to replace
the function of the destroyed pancreatic beta cells in diabetes, islet transplantation is the …