Sulfur (S VI) based moieties, especially, the sulfonyl or sulfonamide based analogues have
showed a variety of pharmacological properties, and its derivatives propose a high degree …

Abstract Carbonic anhydrases (CAs, EC 4.2. 1.1) are widely distributed metalloenzymes in
both prokaryotes and eukaryotes. They efficiently catalyze the reversible hydration of carbon …

Carbonic anhydrases (CAs, EC 4.2. 1.1) are ubiquitous metallo-enzymes, present
throughout most living organisms and encoded by five evolutionarily unrelated gene …

Abstract Carbonic anhydrase (CA, EC 4.2. 1.1) is an enzyme and a very omnipresent zinc
metalloenzyme which catalyzed the reversible hydration and dehydration of carbon dioxide …

The metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1) is ubiquitously expressed in
organisms all over the phylogenetic tree, with seven genetically distinct families known to …

At least 14 different carbonic anhydrase (CA, EC 4.2. 1.1) isoforms were isolated in higher
vertebrates, where these zinc enzymes play crucial physiological roles. Some of these …

The sulfonamides constitute an important class of drugs, with several types of
pharmacological agents possessing antibacterial, anti-carbonic anhydrase, diuretic …

Introduction: Glaucoma is one of the major causes of blindness, affecting together with age-
related macular degeneration> 70 million people worldwide. One of the therapeutic options …

Carbonic anhydrases (CAs, EC 4.2. 1.1) are zinc enzymes acting as efficient catalysts for the
reversible hydration of carbon dioxide to bicarbonate. 16 different α-CA isoforms were …

Introduction: The benzothiadiazines and high ceiling diuretics (hydrochlorothiazide,
hydroflumethiazide, quinethazone, metolazone, chlorthalidone, indapamide, furosemide …