The pulmonary endothelium is a dynamic, metabolically active layer of squamous
endothelial cells ideally placed to mediate key processes involved in lung homoeostasis …

Platelets are essential for physiological hemostasis and are central in pathological
thrombosis. These are their traditional and best known activities in health and disease. In …

The lung is highly vulnerable during sepsis, yet its functional deterioration accompanied by
disturbances in the pulmonary microcirculation is poorly understood. This study aimed to …

The number of leukocytes present in circulation varies throughout the day, reflecting bone
marrow output and emigration from blood into tissues. Using an organism-wide circadian …

It is well established that Ly6Chi monocytes develop from common monocyte progenitors
(cMoPs) and reside in the bone marrow (BM) until they are mobilized into the circulation. In …

Endothelial cells (ECs) constitute small capillary blood vessels and contribute to delivery of
nutrients, oxygen and cellular components to the local tissues, as well as to removal of …

Intravital microscopy (IVM) study approach offers several advantages over in vitro, ex vivo,
and 3D models. IVM provides real-time imaging of cellular events, which provides us a …

Neutrophils, constituting the first line of defense, perform vital functions during immune
surveillance. A key feature that assists in their prompt response to an inflammatory signal is …

Mesenchymal stem/stromal cells (MSCs) are undergoing intensive translational research for
several debilitating conditions, including critical illnesses such as ARDS and sepsis. MSCs …

In this review, we discuss intravital microscopy of immune cells, starting from its historic
origins to current applications in diverse organs. It is clear from a quantitative review of the …