Excess adiposity can induce adverse sequelae in multiple cell types and organ systems.
The transition from the lean to the obese state is characterized by fundamental cellular …

During the past 2 decades, results of both basic science and clinical studies have changed
the physicians' views about adipocyte pathophysiology. Since leptin was discovered in …

Adiponectin is a secretory protein, primarily produced in adipocytes. However, low but
detectable expression of adiponectin can be observed in cell types beyond adipocytes …

Adiponectin is an adipocyte hormone that links visceral adiposity with insulin resistance and
atherosclerosis. It is unique among adipocyte-derived hormones in that its circulating …

Impaired kidney function and chronic kidney disease (CKD) leading to kidney failure and
end-stage renal disease (ESRD) is a serious medical condition associated with increased …

Adiponectin circulates in blood in multiple isoforms. High molecular weight (HMW)
adiponectin is thought to be most biologically active and promotes glucose uptake, insulin …

The widespread physiological actions of adiponectin have now been well characterized as
clinical studies and works in animal models have established strong correlations between …

OBJECTIVE: The number of patients with end-stage renal disease (ESRD) is rising and
these patients are at higher risk of cardiovascular disease. We studied the role of hormonal …

Diabetes mellitus complicates 1-2% of all pregnancies but is associated with high a
perinatal morbidity and mortality. Gestational diabetes affects up to 4% of pregnancies and …

Adiponectin has antidiabetic properties, and patients with obesity, diabetes, and insulin
resistance have low plasma adiponectin levels. However, although kidney disease is …