Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), exhibits a wide spectrum of clinical presentations …

Stroke is the leading cause of adult disability and mortality in most developing and
developed countries. The current best practices for patients with acute ischemic stroke …

Myocardial ischemia-reperfusion injury induces a sterile inflammatory response, leading to
further injury that contributes to the final infarct size. Locally released danger-associated …

Kidney tubular epithelial cells (TECs) have a crucial role in the damage and repair response
to acute and chronic injury. To adequately respond to constant changes in the environment …

Acute myocardial infarction (AMI) is associated with the induction of a sterile inflammatory
response that leads to further injury. The NACHT, leucine-rich repeat, and pyrin domain …

Background/Aims. NLRP3 inflammasome, an inflammasome which consists of nucleotide-
binding oligomerization domain-(Nod-) like receptor3 (NLRP3) scaffold, apoptosis …

Establishing the balance between positive and negative innate immune mechanisms is
crucial for maintaining homeostasis. Here we uncover the regulatory crosstalk between two …

The study aims to investigate the effects of long noncoding RNA (lncRNA) transmitted
nuclear factor-κB interacting lncRNA (NKILA)-containing astrocyte-derived small …

Inflammasome activation leads to pyroptotic cell death, thereby eliminating the replicative
niche of virulent pathogens. Although inflammasome-associated cytokines IL-1β and IL-18 …

Over the last decade, significant progress has been achieved in defining mechanisms
underlying NLR regulation of immune system function. However, several NLR family …