Myocardial infarction (MI) is a myocardial injury caused by coronary thrombosis or persistent
ischemia and hypoxia. Due to its high morbidity and mortality, a safer and more effective …

ncRNAs, particularly miRNAs, lncRNAs and circRNAs, are a group of RNAs which, although
they do not encode proteins (however, recent evidence shows that certain circRNAs are …

Hypoxia–ischemia (HI) is a major cause of brain damage in neonates. Mitochondrial
dysfunction acts as a hub for a broad spectrum of signaling events, culminating in cell death …

Abstract NLRX1 weakens lipopolysaccharide (LPS)-induced NF-κB activation on immune
cells. Cytochrome P450 epoxygenase 2J2 (CYP2J2) attenuates LPS-induced cardiac injury …

Inflammasome activation and pyroptotic cell death are known to contribute to the
pathogenesis of cardiovascular diseases, such as myocardial ischemia-reperfusion (I/R) …

Porcine reproductive and respiratory syndrome virus (PRRSV) causes one of the most
economically important diseases of swine worldwide. Current antiviral strategies provide …

ABSTRACT NOD-like receptor X1 (NLRX1) is known for its unique mitochondrial localization
and plays a negative role in innate immunity. The initial characterization and function of …

Sensing of cytosolic nucleotides is a critical initial step in the elaboration of type I IFN. One of
several upstream receptors, cyclic GMP–AMP synthase, binds to cytosolic DNA and …

Neuroinflammation is a key pathophysiological feature of stroke-associated brain injury. A
local innate immune response triggers neuroinflammation following a stroke via activating …

Background Dysregulated alterations in organelle structure and function have a significant
connection with cell death, as well as the occurrence and development of inflammatory …