It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

Adenosine monophosphate‐activated protein kinase (AMPK) is a cellular energy sensor
activated during energy stress that plays a key role in maintaining energy homeostasis. This …

Complex multicellular organisms require a coordinated response from multiple tissues to
maintain whole-body homeostasis in the face of energetic stressors such as fasting, cold …

The AMP-activated protein kinase (AMPK) is a key regulator of cellular and whole-body
energy homeostasis, which acts to restore energy homoeostasis whenever cellular energy …

AMPK is a serine/threonine protein kinase, which serves as an energy sensor in all
eukaryotic cell types. Published studies indicate that AMPK activation strongly suppresses …

Rational: AMP-activated protein kinase (AMPK) is an energy sensor and ubiquitously
expressed in vascular cells. Recent studies suggest that AMPK activation improves …

Smoking is the only modifiable risk factor that is associated with the development, expansion
and rupture of abdominal aortic aneurysm (AAA). However, the causative link between …

Vascular endothelial cells are highly glycolytic and consume relatively low amounts of
oxygen (O2) compared with other cells. We have confirmed that oxidative phosphorylation is …

The AMP-activated protein kinase (AMPK) was initially identified as the kinase that
phosphorylates the 3-hydroxy 3-methylglutaryl coenzyme A reductase, the rate-limiting …

Obesity-related disorders are closely associated with the pathogenesis of cardiovascular
disease. Adiponectin is a circulating adipose tissue-derived hormone that is down-regulated …