Background The DSM-5 mixed features specifier for mood disorders encourages renewed
interest in mixed states and led us to pool research findings regarding prevalence of mixed …

Objective This systematic review provided a critical synthesis and a comprehensive
overview of guidelines on the treatment of mixed states. Method The MEDLINE/PubMed and …

Background Bipolar disorder (BD) is a chronic mood disorder characterized by recurrent
episodes of mania or hypomania and depression, expressed by changes in energy levels …

Objective. Mixed presentations, defined by simultaneous occurrence of depressive and
manic symptoms, are difficult to treat. Antidepressants, although commonly used, have weak …

Background Systematic data on clinical correlates of mixed features in bipolar disorder are
not available, so far. We conducted a systematic review and meta-analysis estimating the …

Psychiatric disorders vary greatly in suicidal risks, although major mood, psychotic, and
substance abuse disorders are associated with particularly high suicide rates. 1–3 Bipolar …

Mixed features presentation in bipolar disorder (BD) represents the most severe form of the
disease. BD may lead to cognitive and functional deterioration, a process known as …

The aim of this study was to investigate the dose-dependent adverse effects of long-term
dietary lithium administration on specific aspects of the defense system in rats. Additionally …

Background: The demographic profile and clinical manifestations of mood disorder subtypes
can differ across regions; however, there is a lack of studies from Saudi Arabia on the …

Objective: To consider whether consensus exists in recommendations for managing bipolar
mixed states published in recent reviews and treatment guidelines, and to summarise what …