The sympathetic nervous system in the 21st century: Neuroimmune interactions in metabolic homeostasis and obesity

N Martinez-Sanchez, O Sweeney, D Sidarta-Oliveira… - Neuron, 2022 - cell.com
The sympathetic nervous system maintains metabolic homeostasis by orchestrating the
activity of organs such as the pancreas, liver, and white and brown adipose tissues. From …

Obesity: a neuroimmunometabolic perspective

CM Larabee, OC Neely, AI Domingos - Nature Reviews Endocrinology, 2020 - nature.com
Neuroimmunology and immunometabolism are burgeoning topics of study, but the
intersection of these two fields is scarcely considered. This interplay is particularly prevalent …

Interactions between central nervous system and peripheral metabolic organs

W Zeng, F Yang, WL Shen, C Zhan, P Zheng… - Science China Life …, 2022 - Springer
According to Descartes, minds and bodies are distinct kinds of “substance”, and they cannot
have causal interactions. However, in neuroscience, the two-way interaction between the …

[HTML][HTML] Metabolic stress drives sympathetic neuropathy within the liver

K Liu, L Yang, G Wang, J Liu, X Zhao, Y Wang, J Li… - Cell metabolism, 2021 - cell.com
The nervous system instructs the body's metabolism, including that in the liver. However, the
neural anatomy of the liver under either normal or metabolically stressed conditions remains …

Transcriptional repression of beige fat innervation via a YAP/TAZ-S100B axis

X Huang, X Li, H Shen, Y Zhao, Z Zhou, Y Wang… - Nature …, 2023 - nature.com
Sympathetic innervation is essential for the development of functional beige fat that
maintains body temperature and metabolic homeostasis, yet the molecular mechanisms …

The metabolic and functional roles of sensory nerves in adipose tissues

G Mishra, KL Townsend - Nature Metabolism, 2023 - nature.com
Homeostatic regulation of adipose tissue is critical for the maintenance of energy balance
and whole-body metabolism. The peripheral nervous system provides bidirectional neural …

Eosinophils regulate intra-adipose axonal plasticity

X Meng, X Qian, X Ding, W Wang… - Proceedings of the …, 2022 - National Acad Sciences
Sympathetic innervation regulates energy balance, and the nerve density in the adipose
tissues changes under various metabolic states, resulting in altered neuronal control and …

Bone morphogenetic proteins (BMPs) in the central regulation of energy balance and adult neural plasticity

GS Jensen, NE Leon-Palmer, KL Townsend - Metabolism, 2021 - Elsevier
The current worldwide obesity pandemic highlights a need to better understand the
regulation of energy balance and metabolism, including the role of the nervous system in …

Peripheral innervation in the regulation of glucose homeostasis

EE Lin, E Scott-Solomon, R Kuruvilla - Trends in neurosciences, 2021 - cell.com
Precise regulation of circulating glucose is crucial for human health and ensures a sufficient
supply to the brain, which relies almost exclusively on glucose for metabolic energy …

Cause and management of lipedema‐associated pain

H Aksoy, AS Karadag, U Wollina - Dermatologic therapy, 2021 - Wiley Online Library
Lipedema is a painful, underdiagnosed adipose tissue disorder, characterized by
symmetrical swelling of the extremities due to subcutaneous fat deposition in the buttocks …