The main function of the lung is to perform gas exchange while maintaining lung
homeostasis despite environmental pathogenic and non-pathogenic elements contained in …

Alveolar macrophages (AMs) are the sentinel cells of the alveolar space, maintaining
homeostasis, fending off pathogens, and controlling lung inflammation. During acute lung …

Pathogen persistence in the respiratory tract is an important preoccupation, and of particular
relevance to infectious diseases such as tuberculosis. The equilibrium between elimination …

Gas exchange is the vital function of the lungs. It occurs in the alveoli, where oxygen and
carbon dioxide diffuse across the alveolar epithelium and the capillary endothelium …

Six healthy young male volunteers at a contract research organization were enrolled in the
first phase 1 clinical trial of TGN1412, a novel superagonist anti-CD28 monoclonal antibody …

Although there is a modest body of literature on the absorption of inhaled pharmaceuticals
by normal lungs and some limited information from diseased lungs, there is still a surprising …

Because eosinophils recruited into the airways in allergic diseases are exposed to inhaled
allergens, we evaluated whether eosinophils within the endobronchial lumen can function in …

Objective The expression of proinflammatory cytokines is rapidly increased in experimental
models of the acute respiratory distress syndrome (ARDS), in patients at risk for ARDS, and …

purpose. To examine the normal murine corneal stroma for the presence of bone marrow-
derived leukocytes. methods. Wholemounts of paraformaldehyde-fixed corneal stroma from …

Macrophages, the major host cells harboring Mycobacterium tuberculosis (M. tb), are a
heterogeneous cell type depending on their tissue of origin and host they are derived from …