Histone deacetylases (HDACs) are enzymes pursued as drug targets in various cancers and
several non-oncological conditions, such as inflammation and neurodegenerative disorders …

Histone deacetylases (HDACs) catalyze the hydrolysis of acetyl-l-lysine side chains in
histones and non-histones, which are key to epigenetic regulation in humans. Targeting …

Idiopathic pulmonary fibrosis is incurable, and its progression is difficult to control and thus
can lead to pulmonary deterioration. Pan-histone deacetylase inhibitors such as SAHA have …

HDAC6 is predominantly found in the cytoplasm and is mainly responsible for deacetylation
of non-histone proteins including α-tubulin in microtubules, the HSP90 chaperone, cortactin …

Epigenetic regulation of gene expression using histone deacetylase (HDAC) inhibitors is a
promising strategy for developing new anticancer agents. The most common HDAC …

Inherited retinal diseases, which include retinitis pigmentosa, are a family of genetic
disorders characterized by gradual rod-cone degeneration and vision loss, without effective …

Adipose tissues are broadly distributed in human bodies especially of the obese population,
which have long been considered as a surplus proportion. With the advancement of cell …

Herein, we report the development of a new series of histone deacetylase inhibitors (HDACi)
containing a 2-substituted 1, 5-benzothiazepine scaffold. First, a virtual combinatorial library …

Galanin is a 30 amino acid peptide that stimulates three subtype receptors (GAL1–3R).
M89b is a lanthionine-stabilized, C-terminally truncated galanin analog that specifically …