BACKGROUND In adult mammalian organisms, multiple tissues—including the skin, blood,
stomach, and intestines—are entrapped in a state of permanent regeneration; older cells are …

Organoids—Preclinical Models of Disease An organoid is a three-dimensional construct
composed of multiple cell types that originates from stem cells through self-organization and …

Organoids derived from human pluripotent stem cells are a potentially powerful tool for high-
throughput screening (HTS), but the complexity of organoid cultures poses a significant …

Kidney fibrosis is a common histological manifestation of functional decline in the kidney.
Fibrosis is a reactive process that develops in response to excessive epithelial injury and …

Kidney disease is poorly understood because of the organ's cellular diversity. We used
single-cell RNA sequencing not only in resolving differences in injured kidney tissue cellular …

Acute kidney injury (AKI) is considered largely reversible based on the capacity of surviving
tubular cells to dedifferentiate and replace lost cells via cell division. Here we show by …

The acutely injured mammalian kidney mounts a cellular and molecular response to repair
itself. However, in patchy regions such intrinsic processes are impaired and dysregulated …

Background AKI triggers a proliferative response as part of an intrinsic cellular repair
program, which can lead to adaptive renal repair, restoring kidney structure and function, or …

Acute kidney injury (AKI) is defined by a sudden loss of excretory kidney function. AKI is part
of a range of conditions summarized as acute kidney diseases and disorders (AKD), in …

The cellular and mechanistic bases underlying endothelial regeneration of adult large
vessels have proven challenging to study. Using a reproducible in vivo aortic endothelial …